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dc.contributor.authorTruong, L
dc.contributor.authorAllbutt, HN
dc.contributor.authorCoster, MJ
dc.contributor.authorKassiou, M
dc.contributor.authorHenderson, JM
dc.date.accessioned2017-05-03T15:16:51Z
dc.date.available2017-05-03T15:16:51Z
dc.date.issued2009
dc.date.modified2010-09-13T07:10:32Z
dc.identifier.issn0361-9230
dc.identifier.doi10.1016/j.brainresbull.2008.10.004
dc.identifier.urihttp://hdl.handle.net/10072/33920
dc.description.abstractExperimental lesions involving the parafascicular (Pf) nucleus and medial forebrain bundle (MFB) may model to some extent the pathological loss of glutamatergic neurons from the centromedian-parafascicular (CM-Pf) complex and nigral dopaminergic cell loss observed clinically at post-mortem in Parkinson's disease (PD) cases. Our study investigated whether there were alterations in symptomatology in such rats with unilateral 6-OHDA + Pf lesions after treatment with either a selective NR1A/NR2B NMDA antagonist and/or l-dopa. Rats were given dual surgery to the MFB with 6-hydroxydopamine (6-OHDA) and Pf with N-methyl-d-aspartate (NMDA). (i) An NR1A/NR2B selective NMDA antagonist (BZAD-01; 10 mg/kg), (ii) l-dopa (25 mg/kg), (iii) BZAD-01 + l-dopa (10 mg/kg; 25 mg/kg) or (iv) vehicle solution were administered for 6 weeks, during which behavioural testing was performed. BZAD-01 improved postural asymmetry in the first month as well as apomorphine-induced rotation. The latter was also improved by l-dopa in this model. These data support the use of selective NR1/NR2B NMDA antagonists in the therapeutics of PD.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom91
dc.relation.ispartofpageto96
dc.relation.ispartofissue2-3
dc.relation.ispartofjournalBrain Research Bulletin
dc.relation.ispartofvolume78
dc.rights.retentionY
dc.subject.fieldofresearchCell neurochemistry
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode310104
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode5204
dc.titleBehavioural effects of a selective NMDA NR1A/2B receptor antagonist in rats with unilateral 6-OHDA + parafascicular lesions
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorCoster, Mark J.


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