dc.contributor.author | Truong, L | |
dc.contributor.author | Allbutt, HN | |
dc.contributor.author | Coster, MJ | |
dc.contributor.author | Kassiou, M | |
dc.contributor.author | Henderson, JM | |
dc.date.accessioned | 2017-05-03T15:16:51Z | |
dc.date.available | 2017-05-03T15:16:51Z | |
dc.date.issued | 2009 | |
dc.date.modified | 2010-09-13T07:10:32Z | |
dc.identifier.issn | 0361-9230 | |
dc.identifier.doi | 10.1016/j.brainresbull.2008.10.004 | |
dc.identifier.uri | http://hdl.handle.net/10072/33920 | |
dc.description.abstract | Experimental lesions involving the parafascicular (Pf) nucleus and medial forebrain bundle (MFB) may model to some extent the pathological loss of glutamatergic neurons from the centromedian-parafascicular (CM-Pf) complex and nigral dopaminergic cell loss observed clinically at post-mortem in Parkinson's disease (PD) cases. Our study investigated whether there were alterations in symptomatology in such rats with unilateral 6-OHDA + Pf lesions after treatment with either a selective NR1A/NR2B NMDA antagonist and/or l-dopa. Rats were given dual surgery to the MFB with 6-hydroxydopamine (6-OHDA) and Pf with N-methyl-d-aspartate (NMDA). (i) An NR1A/NR2B selective NMDA antagonist (BZAD-01; 10 mg/kg), (ii) l-dopa (25 mg/kg), (iii) BZAD-01 + l-dopa (10 mg/kg; 25 mg/kg) or (iv) vehicle solution were administered for 6 weeks, during which behavioural testing was performed. BZAD-01 improved postural asymmetry in the first month as well as apomorphine-induced rotation. The latter was also improved by l-dopa in this model. These data support the use of selective NR1/NR2B NMDA antagonists in the therapeutics of PD. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 91 | |
dc.relation.ispartofpageto | 96 | |
dc.relation.ispartofissue | 2-3 | |
dc.relation.ispartofjournal | Brain Research Bulletin | |
dc.relation.ispartofvolume | 78 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Cell neurochemistry | |
dc.subject.fieldofresearch | Neurosciences | |
dc.subject.fieldofresearch | Cognitive and computational psychology | |
dc.subject.fieldofresearchcode | 310104 | |
dc.subject.fieldofresearchcode | 3209 | |
dc.subject.fieldofresearchcode | 5204 | |
dc.title | Behavioural effects of a selective NMDA NR1A/2B receptor antagonist in rats with unilateral 6-OHDA + parafascicular lesions | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2009 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Coster, Mark J. | |