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  • Micro in-focal cell stretching platform with parallel programmable control

    Author(s)
    Huang, Y
    Nguyen, NT
    Griffith University Author(s)
    Nguyen, Nam-Trung
    Year published
    2012
    Metadata
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    Abstract
    This paper reports a micro-scale programmable cell stretching platform. The platform keeps the cell monolayer in the microscopic focal plane throughout the stretching process allowing real-time imaging of the cells with magnifications up to 40×, and post-stretching optical analysis with magnification up to 100×. The device consists of highly parallelized stretching array of 15 units with reconfigurable strains. Each unit was an assembly of three elastomeric layers and a bottom glass cover-slip. In the middle of the assembly, an 8 μm thick membrane is used as the stretching substrate for the cells. A programmable pneumatic ...
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    This paper reports a micro-scale programmable cell stretching platform. The platform keeps the cell monolayer in the microscopic focal plane throughout the stretching process allowing real-time imaging of the cells with magnifications up to 40×, and post-stretching optical analysis with magnification up to 100×. The device consists of highly parallelized stretching array of 15 units with reconfigurable strains. Each unit was an assembly of three elastomeric layers and a bottom glass cover-slip. In the middle of the assembly, an 8 μm thick membrane is used as the stretching substrate for the cells. A programmable pneumatic control system provides actuation. The stretching of the membrane is measured in situ using µPIV technique. The results show that a uniform strain of above 60% can be achieved. Preliminary cell stretching experiments in this device with 5 different cell lines were conducted. Both the acute cell deformation and chronic morphological changes in response to the cyclic strain have confirmed the functionality of this platform.
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    Conference Title
    Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
    Publisher URI
    http://www.rsc.org/images/loc/2012/html/index.html
    Subject
    Medical biotechnology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/339314
    Collection
    • Conference outputs

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