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dc.contributor.authorNadeem, K
dc.contributor.authorNg, BC
dc.contributor.authorLim, E
dc.contributor.authorGregory, SD
dc.contributor.authorSalamonsen, RF
dc.contributor.authorStevens, MC
dc.contributor.authorMubin, M
dc.contributor.authorLovell, NH
dc.date.accessioned2017-08-25T12:31:42Z
dc.date.available2017-08-25T12:31:42Z
dc.date.issued2016
dc.identifier.issn0090-6964
dc.identifier.doi10.1007/s10439-015-1388-2
dc.identifier.urihttp://hdl.handle.net/10072/339385
dc.description.abstractAs a left ventricular assist device is designed to pump against the systemic vascular resistance (SVR), pulmonary congestion may occur when using such device for right ventricular support. The present study evaluates the efficacy of using a fixed right outflow banding in patients receiving biventricular assist device support under various circulatory conditions, including variations in the SVR, pulmonary vascular resistance (PVR), total blood volume (BV), as well as ventricular contractility. Effect of speed variation on the hemodynamics was also evaluated at varying degrees of PVR. Pulmonary congestion was observed at high SVR and BV. A reduction in right ventricular assist device (RVAD) speed was required to restore pulmonary pressures. Meanwhile, at a high PVR, the risk of ventricular suction was prevalent during systemic hypotension due to low SVR and BV. This could be compensated by increasing RVAD speed. Isolated right heart recovery may aggravate pulmonary congestion, as the failing left ventricle cannot accommodate the resultant increase in the right-sided flow. Compared to partial assistance, the sensitivity of the hemodynamics to changes in VAD speed increased during full assistance. In conclusion, our results demonstrated that the introduction of a banding graft with a 5 mm diameter guaranteed sufficient reserve of the pump speed spectrum for the regulation of acceptable hemodynamics over different clinical scenarios, except under critical conditions where drug administration or volume management is required.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofpagefrom1008
dc.relation.ispartofpageto1018
dc.relation.ispartofissue4
dc.relation.ispartofjournalAnnals of Biomedical Engineering
dc.relation.ispartofvolume44
dc.subject.fieldofresearchMedical Devices
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode090304
dc.subject.fieldofresearchcode09
dc.subject.fieldofresearchcode11
dc.titleNumerical Simulation of biventricular assist device with fixed right outflow cannula banding during pulmonary hypertension
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorGregory, Shaun D.


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