A bidirectional synthesis of spiroacetals via Rh(II)-catalysed C–H insertion
Author(s)
Lepage, Romain J
White, Jonathan M
Coster, Mark J
Year published
2017
Metadata
Show full item recordAbstract
Acyclic methylene acetals bearing two diazoester subunits have been converted to [5,5]-spiroacetals VIA bidirectional C–H insertion under Rh(II) catalysis. Using a chiral Rh(II) catalyst, the major diastereomer can be produced in high enantiomeric excess (89%).Acyclic methylene acetals bearing two diazoester subunits have been converted to [5,5]-spiroacetals VIA bidirectional C–H insertion under Rh(II) catalysis. Using a chiral Rh(II) catalyst, the major diastereomer can be produced in high enantiomeric excess (89%).
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Journal Title
Chemical Communications
Volume
53
Issue
30
Subject
Chemical sciences
Other chemical sciences not elsewhere classified