A bidirectional synthesis of spiroacetals via Rh(II)-catalysed C–H insertion
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Acyclic methylene acetals bearing two diazoester subunits have been converted to [5,5]-spiroacetals VIA bidirectional C–H insertion under Rh(II) catalysis. Using a chiral Rh(II) catalyst, the major diastereomer can be produced in high enantiomeric excess (89%).
Chemical Sciences not elsewhere classified