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dc.contributor.authorL. Varich, Nataliaen_US
dc.contributor.authorS. Kochergin-Nikitsky, Konstantinen_US
dc.contributor.authorV. Usachev, Evgenyen_US
dc.contributor.authorV. Usacheva, Olgaen_US
dc.contributor.authorG. Prilipov, Alexeien_US
dc.contributor.authorG. Webster, Roberten_US
dc.contributor.authorV. Kaverin, Nikolaien_US
dc.date.accessioned2017-05-03T15:30:48Z
dc.date.available2017-05-03T15:30:48Z
dc.date.issued2009en_US
dc.date.modified2010-09-15T07:05:29Z
dc.identifier.issn00221317en_US
dc.identifier.doi10.1099/vir.0.010660-0en_AU
dc.identifier.urihttp://hdl.handle.net/10072/33957
dc.description.abstractThe locations of amino acid positions relevant to antigenic variation in the nucleoprotein (NP) of influenza virus are not conclusively known. We analysed the antigenic structure of influenza A virus NP by introducing site-specific mutations at amino acid positions presumed to be relevant for the differentiation of strain differences by anti-NP monoclonal antibodies. Mutant proteins were expressed in a prokaryotic system and analysed by performing ELISA with monoclonal antibodies. Four amino acid residues were found to determine four different antibody-binding sites. When mapped in a 3D X-ray model of NP, the four antigenically relevant amino acid positions were found to be located in separate physical sites of the NP molecule.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSociety for General Microbiologyen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1730en_US
dc.relation.ispartofpageto1733en_US
dc.relation.ispartofissue7en_US
dc.relation.ispartofjournalJournal of General Virologyen_US
dc.relation.ispartofvolume90en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchVirologyen_US
dc.subject.fieldofresearchcode060506en_US
dc.titleLocation of antigenic sites recognized by monoclonal antibodies in the influenza A virus nucleoprotein moleculeen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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