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dc.contributor.authorIslam, Md Nazmul
dc.contributor.authorMasud, Mostafa Kamal
dc.contributor.authorHaque, Md Hakimul
dc.contributor.authorAl Hossain, Md Shahriar
dc.contributor.authorYamauchi, Yusuke
dc.contributor.authorNam-Trung, Nguyen
dc.contributor.authorShiddiky, Muhammad JA
dc.date.accessioned2017-06-22T04:26:54Z
dc.date.available2017-06-22T04:26:54Z
dc.date.issued2017
dc.identifier.issn2366-9608
dc.identifier.doi10.1002/smtd.201700131
dc.identifier.urihttp://hdl.handle.net/10072/339657
dc.description.abstractRibonucleic acids (RNAs) are considered as effective and minimally invasive biomarkers for disease diagnosis and prognosis due to their critical role in the regulation of different cellular processes. Over the past several years, the rapid progress in RNA biomarker research has resulted in the development of a large number of high-performance RNA-detection methods. Most of these methods are based on molecular-biology techniques such as quantitative reverse transcription polymerase chain reaction (RT-qPCR), microarrays, and RNA sequencing. In recent years, considerable attention has also been dedicated to developing RNA biosensors, exploiting micro- and nanofabrication technologies, and various readout strategies, including electrochemical and optical transducers. Here, the recent developments of RNA biosensors are concisely reviewed with a special emphasis on electrochemical-detection approaches. The following points are also highlighted: i) all the types of clinically relevant RNAs (mRNAs, miRNAs, lncRNAs) and their diagnostic and prognostic potential in cancer are outlined, ii) major challenges associated with current techniques are identified, followed by a critical analysis of how these challenges have been addressed by different biosensing approaches, and iii) the current requirements that still need to be met for effective screening of RNA biomarkers in both research and clinical settings.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA
dc.relation.ispartofpagefrom1700131-1
dc.relation.ispartofpageto1700131-20
dc.relation.ispartofjournalSmall Methods
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences not elsewhere classified
dc.subject.fieldofresearchcode111599
dc.titleRNA Biomarkers: Diagnostic and Prognostic Potentials and Recent Developments of Electrochemical Biosensors
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.facultyGriffith Sciences, School of Natural Sciences
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2017 Wiley-Blackwell. This is the peer reviewed version of the following article: RNA Biomarkers: Diagnostic and Prognostic Potentials and Recent Developments of Electrochemical Biosensors Small Methods, 2017 which has been published in final form at 10.1002/smtd.201700131. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.hasfulltextFull Text
gro.griffith.authorHaque, Md. Hakimul H.
gro.griffith.authorNguyen, Nam-Trung
gro.griffith.authorShiddiky, Muhammad J.
gro.griffith.authorMasud, Mostafa Kamal K.
gro.griffith.authorIslam, Nazmul


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