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dc.contributor.authorScott, Philip D
dc.contributor.authorColeman, Heather M
dc.contributor.authorColville, Anne
dc.contributor.authorLim, Richard
dc.contributor.authorMatthews, Benjamin
dc.contributor.authorMcDonald, James A
dc.contributor.authorMiranda, Ana
dc.contributor.authorNeale, Peta A
dc.contributor.authorNugegoda, Dayanthi
dc.contributor.authorTremblay, Louis A
dc.contributor.authorLeusch, Frederic DL
dc.date.accessioned2017-06-12T23:45:10Z
dc.date.available2017-06-12T23:45:10Z
dc.date.issued2017
dc.identifier.issn0166-445X
dc.identifier.doi10.1016/j.aquatox.2017.02.008
dc.identifier.urihttp://hdl.handle.net/10072/339669
dc.description.abstractIn Australia, trace organic contaminants (TrOCs) and endocrine active compounds (EACs) have been detected in rivers impacted by sewage effluent, urban stormwater, agricultural and industrial inputs. It is unclear whether these chemicals are at concentrations that can elicit endocrine disruption in Australian fish species. In this study, native rainbowfish (Melanotaenia fluviatilis) and introduced invasive (but prevalent) mosquitofish (Gambusia holbrooki) were exposed to the individual compounds atrazine, estrone, bisphenol A, propylparaben and pyrimethanil, and mixtures of compounds including hormones and personal care products, industrial compounds, and pesticides at environmentally relevant concentrations. Vitellogenin (Vtg) protein and liver Vtg mRNA induction were used to assess the estrogenic potential of these compounds. Vtg expression was significantly affected in both species exposed to estrone at concentrations that leave little margin for safety (p < 0.001). Propylparaben caused a small but statistically significant 3× increase in Vtg protein levels (p = 0.035) in rainbowfish but at a concentration 40× higher than that measured in the environment, therefore propylparaben poses a low risk of inducing endocrine disruption in fish. Mixtures of pesticides and a mixture of hormones, pharmaceuticals, industrial compounds and pesticides induced a small but statistically significant increase in plasma Vtg in rainbowfish, but did not affect mosquitofish Vtg protein or mRNA expression. These results suggest that estrogenic activity represents a low risk to fish in most Australian rivers monitored to-date except for some species of fish at the most polluted sites.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom105
dc.relation.ispartofpageto120
dc.relation.ispartofjournalAquatic Toxicology
dc.relation.ispartofvolume185
dc.relation.urihttp://purl.org/au-research/grants/ARC/LP100100163
dc.relation.grantIDLP100100163
dc.relation.fundersARC
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchEnvironmental sciences
dc.subject.fieldofresearchEnvironmental management not elsewhere classified
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode41
dc.subject.fieldofresearchcode410499
dc.subject.fieldofresearchcode31
dc.titleAssessing the potential for trace organic contaminants commonly found in Australian rivers to induce vitellogenin in the native rainbowfish (Melanotaenia fluviatilis) and the introduced mosquitofish (Gambusia holbrooki)
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, Griffith School of Environment
gro.hasfulltextNo Full Text
gro.griffith.authorLeusch, Frederic
gro.griffith.authorNeale, Peta A.


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