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dc.contributor.authorKolarich, Daniel
dc.contributor.authorRapp, Erdmann
dc.contributor.authorStruwe, Weston B
dc.contributor.authorHaslam, Stuart M
dc.contributor.authorZaia, Joseph
dc.contributor.authorMcBride, Ryan
dc.contributor.authorAgravat, Sanjay
dc.contributor.authorCampbell, Matthew P
dc.contributor.authorKato, Masaki
dc.contributor.authorRanzinger, Rene
dc.contributor.authorKettner, Carsten
dc.contributor.authorYork, William S
dc.date.accessioned2017-06-13T01:16:34Z
dc.date.available2017-06-13T01:16:34Z
dc.date.issued2013
dc.identifier.issn1535-9476
dc.identifier.doi10.1074/mcp.O112.026492
dc.identifier.urihttp://hdl.handle.net/10072/339715
dc.description.abstractThe MIRAGE guidelines are being developed in response to a critical need in the glycobiology community to clarify glycoanalytic results so that they are more readily evaluated (in terms of their scope and depth) and to facilitate the reproduction of important results in the laboratory. The molecular and biological complexity of the glycosylation process makes thorough reporting of the results of a glycomics experiment a highly challenging endeavor. The resulting data specify the identity and quantity of complex structures, the precise molecular features of which are sometimes inferred using prior knowledge, such as familiarity with a particular biosynthetic mechanism. Specifying the exact methods and assumptions that were used to assign and quantify reported structures allows the interested scientist to appreciate the scope and depth of the analysis. Mass spectrometry (MS) is the most widely used tool for glycomics experiments. The interpretation and reproducibility of MS-based glycomics data depend on comprehensive meta-data describing the instrumentation, instrument setup, and data acquisition protocols. The MIRAGE guidelines for MS-based glycomics have been designed to facilitate the collection and sharing of this critical information in order to assist the glycoanalyst in generating data sets with maximum information content and biological relevance.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society for Biochemistry and Molecular Biology
dc.relation.ispartofpagefrom991
dc.relation.ispartofpageto995
dc.relation.ispartofissue4
dc.relation.ispartofjournalMolecular and Cellular Proteomics
dc.relation.ispartofvolume12
dc.subject.fieldofresearchAnalytical chemistry not elsewhere classified
dc.subject.fieldofresearchcode340199
dc.titleThe minimum information required for a glycomics experiment (MIRAGE) project: Improving the standards for reporting mass-spectrometry-based glycoanalytic data
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.rights.copyrightThis research was originally published in Molecular & Cellular Proteomics (MCP). Kolarich et al, The minimum information required for a glycomics experiment (MIRAGE) project: Improving the standards for reporting mass-spectrometry-based glycoanalytic data, Molecular & Cellular Proteomics (MCP)  2013; 12: 991-995. Copyright the American Society for Biochemistry and Molecular Biology. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitve version.
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gro.griffith.authorKolarich, Daniel


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