Minimum Information Required for a Glycomics Experiment (MIRAGE): Enhancing the Value of Glycoanalytic Data
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Glycomics is an emerging discipline that seeks to identify and quantify the complex carbohydrates in an organism, tissue, or cell type in order to understand their functions in diverse biological contexts. Recent advances in the analytical technology used for this purpose have dramatically increased the amount of glycomics data that is being generated, interpreted, and published. However, the intrinsic challenges of identifying individual glycans in complex biological samples almost always make it necessary for the glycoanalyst to make fundamental assumptions about the structures present in the sample. The Minimum Information Required for A Glycomics Experiment (MIRAGE) guidelines aim to enhance the value of glycomics data by encouraging analysts to report the experimental conditions under which their data were generated and the assumptions they made when interpreting those data. This chapter discusses some of the major challenges of glycoanalysis and the efforts of the MIRAGE consortium to help glycoscientists and publishers cope with these challenges.
Glycoscience: Biology and Medicine
Biochemistry and Cell Biology not elsewhere classified