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  • Stem cell therapies in preclinical models of stroke. Is the aged brain microenvironment refractory to cell therapy?

    Author(s)
    Sandu, Raluca Elena
    Balseanu, Adrian Tudor
    Bogdan, Catalin
    Slevin, Mark
    Petcu, Eugen
    Popa-Wagner, Aurel
    Griffith University Author(s)
    Petcu, Eugen B.
    Popa-Wagner, Aurel
    Year published
    2017
    Metadata
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    Abstract
    Stroke is a devastating disease demanding vigorous search for new therapies. Initial enthusiasm to stimulate restorative processes in the ischemic brain by means of cell-based therapies has meanwhile converted into a more balanced view recognizing impediments that may be related to unfavorable age-associated environments. Recent results using a variety of drug, cell therapy or combination thereof suggest that, (i) treatment with Granulocyte-Colony Stimulating Factor (G-CSF) in aged rats has primarily a beneficial effect on functional outcome most likely via supportive cellular processes such as neurogenesis; (ii) the combination ...
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    Stroke is a devastating disease demanding vigorous search for new therapies. Initial enthusiasm to stimulate restorative processes in the ischemic brain by means of cell-based therapies has meanwhile converted into a more balanced view recognizing impediments that may be related to unfavorable age-associated environments. Recent results using a variety of drug, cell therapy or combination thereof suggest that, (i) treatment with Granulocyte-Colony Stimulating Factor (G-CSF) in aged rats has primarily a beneficial effect on functional outcome most likely via supportive cellular processes such as neurogenesis; (ii) the combination therapy, G-CSF with mesenchymal cells (G-CSF + BM-MSC or G-CSF + BM-MNC) did not further improve behavioral indices, neurogenesis or infarct volume as compared to G-CSF alone in aged animals; (iii) better results with regard to integration of transplanted cells in the aged rat environment have been obtained using iPS of human origin; (iv) mesenchymal cells may be used as drug carriers for the aged post-stroke brains. Conclusion: While the middle aged brain does not seem to impair drug and cell therapies, in a real clinical practice involving older post-stroke patients, successful regenerative therapies would have to be carried out for a much longer time.
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    Journal Title
    Experimental Gerontology
    DOI
    https://doi.org/10.1016/j.exger.2017.01.008
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Central Nervous System
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/340088
    Collection
    • Journal articles

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