Show simple item record

dc.contributor.authorRenshaw, Gillianen_US
dc.contributor.authorMulvey, Jamin.en_US
dc.date.accessioned2017-04-24T10:56:02Z
dc.date.available2017-04-24T10:56:02Z
dc.date.issued2000en_US
dc.identifier.issn03043940en_US
dc.identifier.doi10.1016/S0304-3940(00)01321-5en_US
dc.identifier.urihttp://hdl.handle.net/10072/3400
dc.description.abstractReduced oxidative demand or neuronal hypometabolism is a neuroprotective strategy used by several anoxia and hypoxia-tolerant species. The epaulette shark, Hemiscyllium ocellatum inhabits shallow reef platforms that can become hypoxic. Hypoxic pre-conditioning (eight cycles of 0.34 mg O2/l for 120 min, 12 h apart) was used to determine whether a reduction in oxidative metabolism could be elicited in the epaulette shark brain. Hypoxic pre-conditioning resulted in a significant overall reduction in oxidative activity in coronal sections of the brainstem, but key nuclei displayed heterogeneous levels of oxidative metabolism. Motor nuclei had significantly lower levels of oxidative activity while sensory nuclei did not. The epaulette shark's ability to enter this state of hypometabolism in response to hypoxic pre-conditioning revealed a neuroprotective mechanism, which would not only reduce neuronal damage during hypoxic exposure but also minimise re-oxygenation injury.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherElsevier Science Irelanden_US
dc.publisher.placeIrelanden_US
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto4en_US
dc.relation.ispartofjournalNeuroscience Lettersen_US
dc.relation.ispartofvolume290en_US
dc.subject.fieldofresearchcode320000en_US
dc.subject.fieldofresearchcode320702en_US
dc.titleNeuronal oxidative hypometabolism in the brainstem of the epaulette shark(Hemiscyllium ocellatum) in response to hypoxic pre-conditioningen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2015-05-06T21:36:31Z
gro.hasfulltextNo Full Text


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record