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  • Microfluidic Technology for the Generation of Cell Spheroids and Their Applications

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    VadiveluPUB4284.pdf (1.406Mb)
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    Author(s)
    Vadivelu, Raja K
    Kamble, Harshad
    Shiddiky, Muhammad JA
    Nguyen, Nam-Trung
    Griffith University Author(s)
    Nguyen, Nam-Trung
    Vadivelu, Raja
    Shiddiky, Muhammad J.
    Year published
    2017
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    Abstract
    A three-dimensional (3D) tissue model has significant advantages over the conventional two-dimensional (2D) model. A 3D model mimics the relevant in-vivo physiological conditions, allowing a cell culture to serve as an effective tool for drug discovery, tissue engineering, and the investigation of disease pathology. The present reviews highlight the recent advances and the development of microfluidics based methods for the generation of cell spheroids. The paper emphasizes on the application of microfluidic technology for tissue engineering including the formation of multicellular spheroids (MCS). Further, the paper discusses ...
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    A three-dimensional (3D) tissue model has significant advantages over the conventional two-dimensional (2D) model. A 3D model mimics the relevant in-vivo physiological conditions, allowing a cell culture to serve as an effective tool for drug discovery, tissue engineering, and the investigation of disease pathology. The present reviews highlight the recent advances and the development of microfluidics based methods for the generation of cell spheroids. The paper emphasizes on the application of microfluidic technology for tissue engineering including the formation of multicellular spheroids (MCS). Further, the paper discusses the recent technical advances in the integration of microfluidic devices for MCS-based high-throughput drug screening. The review compares the various microfluidic techniques and finally provides a perspective for the future opportunities in this research area
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    Journal Title
    Micromachines
    Volume
    8
    Issue
    4
    DOI
    https://doi.org/10.3390/mi8040094
    Copyright Statement
    © 2017 The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY 4.0) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Biomaterials
    Nanotechnology
    Publication URI
    http://hdl.handle.net/10072/340261
    Collection
    • Journal articles

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