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dc.contributor.authorVadivelu, Raja K
dc.contributor.authorKamble, Harshad
dc.contributor.authorShiddiky, Muhammad JA
dc.contributor.authorNguyen, Nam-Trung
dc.date.accessioned2018-07-27T01:30:30Z
dc.date.available2018-07-27T01:30:30Z
dc.date.issued2017
dc.identifier.issn2072-666X
dc.identifier.doi10.3390/mi8040094
dc.identifier.urihttp://hdl.handle.net/10072/340261
dc.description.abstractA three-dimensional (3D) tissue model has significant advantages over the conventional two-dimensional (2D) model. A 3D model mimics the relevant in-vivo physiological conditions, allowing a cell culture to serve as an effective tool for drug discovery, tissue engineering, and the investigation of disease pathology. The present reviews highlight the recent advances and the development of microfluidics based methods for the generation of cell spheroids. The paper emphasizes on the application of microfluidic technology for tissue engineering including the formation of multicellular spheroids (MCS). Further, the paper discusses the recent technical advances in the integration of microfluidic devices for MCS-based high-throughput drug screening. The review compares the various microfluidic techniques and finally provides a perspective for the future opportunities in this research area
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherMDPI
dc.relation.ispartofpagefrom94-1
dc.relation.ispartofpageto94-23
dc.relation.ispartofissue4
dc.relation.ispartofjournalMicromachines
dc.relation.ispartofvolume8
dc.subject.fieldofresearchBiomaterials
dc.subject.fieldofresearchNanotechnology
dc.subject.fieldofresearchcode090301
dc.subject.fieldofresearchcode1007
dc.titleMicrofluidic Technology for the Generation of Cell Spheroids and Their Applications
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionPublished
gro.facultyGriffith Sciences, School of Environment and Science
gro.rights.copyright© 2017 The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY 4.0) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorNguyen, Nam-Trung
gro.griffith.authorVadivelu, Raja
gro.griffith.authorShiddiky, Muhammad J.
gro.griffith.authorKamble, Harshad C.


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