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dc.contributor.authorSrikhanta, Yogitha N
dc.contributor.authorFox, Kate L
dc.contributor.authorJennings, Michael P
dc.date.accessioned2017-05-03T13:23:29Z
dc.date.available2017-05-03T13:23:29Z
dc.date.issued2010
dc.date.modified2010-09-16T08:19:07Z
dc.identifier.issn1740-1526
dc.identifier.doi10.1038/nrmicro2283
dc.identifier.urihttp://hdl.handle.net/10072/34029
dc.description.abstractIn several host-adapted pathogens, phase variation has been found to occur in genes that encode methyltransferases associated with type III restriction-modification systems. It was recently shown that in the human pathogens Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis phase variation of a type III DNA methyltransferase, encoded by members of the mod gene family, regulates the expression of multiple genes. This novel genetic system has been termed the 'phasevarion' (phase-variable regulon). The wide distribution of phase-variable mod family genes indicates that this may be a common strategy used by host-adapted bacterial pathogens to randomly switch between distinct cell types.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMacmillan Publishers
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom196
dc.relation.ispartofpageto206
dc.relation.ispartofissue3
dc.relation.ispartofjournalNature Reviews: Microbiology
dc.relation.ispartofvolume8
dc.rights.retentionY
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchMicrobial genetics
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode310704
dc.subject.fieldofresearchcode3207
dc.titleThe phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorJennings, Michael P.
gro.griffith.authorSrikhanta, Yogitha N.


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