dc.contributor.author | Cox, Amanda J. | |
dc.contributor.author | Hsu, Fang-Chi | |
dc.contributor.author | Ng, Maggie C.Y. | |
dc.contributor.author | Langefeld, Carl D. | |
dc.contributor.author | Freedman, Barry I. | |
dc.contributor.author | Carr, J. Jeffrey | |
dc.contributor.author | Bowden, Donald W. | |
dc.date.accessioned | 2017-06-20T00:15:29Z | |
dc.date.available | 2017-06-20T00:15:29Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0149-5992 | |
dc.identifier.doi | 10.2337/dc13-1514 | |
dc.identifier.uri | http://hdl.handle.net/10072/340380 | |
dc.description.abstract | OBJECTIVE: Given the high rates of cardiovascular disease (CVD) and associated mortality in individuals with type 2 diabetes, identifying and understanding predictors of CVD events and mortality could help inform clinical management in this high-risk group. Recent large-scale genetic studies may provide additional tools in this regard. RESEARCH DESIGN AND METHODS: Genetic risk scores (GRSs) were constructed in 1,175 self-identified European American (EA) individuals comprising the family-based Diabetes Heart Study based on 1) 13 single nucleotide polymorphisms (SNPs) and 2) 30 SNPs with previously documented associations with CVD in genome-wide association studies. Associations between each GRS and a self-reported history of CVD, coronary artery calcified plaque (CAC) determined by noncontrast computed tomography scan, all-cause mortality, and CVD mortality were examined using marginal models with generalized estimating equations and Cox proportional hazards models. RESULTS: The weighted 13-SNP GRS was associated with prior CVD (odds ratio [OR] 1.51 [95% CI 1.22–1.86]; P = 0.0002), CAC (β-coefficient [β] 0.22 [0.02–0.43]; P = 0.04) and CVD mortality (hazard ratio [HR] 1.35 [1.10–1.81]; P = 0.04) when adjusting for the other known CVD risk factors: age, sex, type 2 diabetes affection status, BMI, current smoking status, hypertension, and dyslipidemia. The weighted 30-SNP GRS was also associated with prior CVD (OR 1.33 [1.08–1.65]; P = 0.008), CAC (β 0.29 [0.08–0.50]; P = 0.006), all-cause mortality (HR 1.28 [1.05–1.56]; P = 0.01), and CVD mortality (HR 1.46 [1.08–1.96]; P = 0.01). CONCLUSIONS: These findings support the utility of two simple GRSs in examining genetic associations for adverse outcomes in EAs with type 2 diabetes. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Diabetes Association | |
dc.relation.ispartofpagefrom | 1157 | |
dc.relation.ispartofpageto | 1164 | |
dc.relation.ispartofissue | 4 | |
dc.relation.ispartofjournal | Diabetes Care | |
dc.relation.ispartofvolume | 37 | |
dc.subject.fieldofresearch | Clinical Sciences not elsewhere classified | |
dc.subject.fieldofresearch | Medical and Health Sciences | |
dc.subject.fieldofresearchcode | 110399 | |
dc.subject.fieldofresearchcode | 11 | |
dc.title | Genetic risk score associations with cardiovascular disease and mortality in the Diabetes Heart Study | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Cox, Amanda J. | |