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dc.contributor.authorCox, Amanda J.
dc.contributor.authorHsu, Fang-Chi
dc.contributor.authorNg, Maggie C.Y.
dc.contributor.authorLangefeld, Carl D.
dc.contributor.authorFreedman, Barry I.
dc.contributor.authorCarr, J. Jeffrey
dc.contributor.authorBowden, Donald W.
dc.date.accessioned2017-06-20T00:15:29Z
dc.date.available2017-06-20T00:15:29Z
dc.date.issued2014
dc.identifier.issn0149-5992
dc.identifier.doi10.2337/dc13-1514
dc.identifier.urihttp://hdl.handle.net/10072/340380
dc.description.abstractOBJECTIVE: Given the high rates of cardiovascular disease (CVD) and associated mortality in individuals with type 2 diabetes, identifying and understanding predictors of CVD events and mortality could help inform clinical management in this high-risk group. Recent large-scale genetic studies may provide additional tools in this regard. RESEARCH DESIGN AND METHODS: Genetic risk scores (GRSs) were constructed in 1,175 self-identified European American (EA) individuals comprising the family-based Diabetes Heart Study based on 1) 13 single nucleotide polymorphisms (SNPs) and 2) 30 SNPs with previously documented associations with CVD in genome-wide association studies. Associations between each GRS and a self-reported history of CVD, coronary artery calcified plaque (CAC) determined by noncontrast computed tomography scan, all-cause mortality, and CVD mortality were examined using marginal models with generalized estimating equations and Cox proportional hazards models. RESULTS: The weighted 13-SNP GRS was associated with prior CVD (odds ratio [OR] 1.51 [95% CI 1.22–1.86]; P = 0.0002), CAC (β-coefficient [β] 0.22 [0.02–0.43]; P = 0.04) and CVD mortality (hazard ratio [HR] 1.35 [1.10–1.81]; P = 0.04) when adjusting for the other known CVD risk factors: age, sex, type 2 diabetes affection status, BMI, current smoking status, hypertension, and dyslipidemia. The weighted 30-SNP GRS was also associated with prior CVD (OR 1.33 [1.08–1.65]; P = 0.008), CAC (β 0.29 [0.08–0.50]; P = 0.006), all-cause mortality (HR 1.28 [1.05–1.56]; P = 0.01), and CVD mortality (HR 1.46 [1.08–1.96]; P = 0.01). CONCLUSIONS: These findings support the utility of two simple GRSs in examining genetic associations for adverse outcomes in EAs with type 2 diabetes.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Diabetes Association
dc.relation.ispartofpagefrom1157
dc.relation.ispartofpageto1164
dc.relation.ispartofissue4
dc.relation.ispartofjournalDiabetes Care
dc.relation.ispartofvolume37
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode11
dc.titleGenetic risk score associations with cardiovascular disease and mortality in the Diabetes Heart Study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorCox, Amanda J.


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