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  • Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes

    Author(s)
    Raffield, Laura M.
    Brenes, Gretchen A.
    Cox, Amanda J.
    Freedman, Barry I.
    Hugenschmidt, Christina E.
    Hsu, Fang-Chi
    Xu, Jianzhao
    Wagner, Benjamin C.
    Williamson, Jeff D.
    Maldjian, Joseph A.
    Bowden, Donald W.
    Griffith University Author(s)
    Cox, Amanda J.
    Year published
    2016
    Metadata
    Show full item record
    Abstract
    Aims: Anxiety, depression, accelerated cognitive decline, and increased risk of dementia are observed in individuals with type 2 diabetes. Anxiety and depression may contribute to lower performance on cognitive tests and differences in neuroimaging observed in individuals with type 2 diabetes. Methods: These relationships were assessed in 655 European Americans with type 2 diabetes from 504 Diabetes Heart Study families. Participants completed cognitive testing, brain magnetic resonance imaging, the Brief Symptom Inventory Anxiety subscale, and the Center for Epidemiologic Studies Depression-10. Results: In analyses adjusted ...
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    Aims: Anxiety, depression, accelerated cognitive decline, and increased risk of dementia are observed in individuals with type 2 diabetes. Anxiety and depression may contribute to lower performance on cognitive tests and differences in neuroimaging observed in individuals with type 2 diabetes. Methods: These relationships were assessed in 655 European Americans with type 2 diabetes from 504 Diabetes Heart Study families. Participants completed cognitive testing, brain magnetic resonance imaging, the Brief Symptom Inventory Anxiety subscale, and the Center for Epidemiologic Studies Depression-10. Results: In analyses adjusted for age, sex, educational attainment, and use of psychotropic medications, individuals with comorbid anxiety and depression symptoms had lower performance on all cognitive testing measures assessed (p ≤ 0.005). Those with both anxiety and depression also had increased white matter lesion volume (p = 0.015), decreased gray matter cerebral blood flow (p = 4.43 × 10− 6), decreased gray matter volume (p = 0.002), increased white and gray matter mean diffusivity (p ≤ 0.001), and decreased white matter fractional anisotropy (p = 7.79 × 10− 4). These associations were somewhat attenuated upon further adjustment for health status related covariates. Conclusions: Comorbid anxiety and depression symptoms were associated with cognitive performance and brain structure in a European American cohort with type 2 diabetes.
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    Journal Title
    Journal of Diabetes and its Complications
    Volume
    30
    Issue
    1
    DOI
    https://doi.org/10.1016/j.jdiacomp.2015.09.010
    Subject
    Clinical Sciences not elsewhere classified
    Clinical Sciences
    Publication URI
    http://hdl.handle.net/10072/340386
    Collection
    • Journal articles

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