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dc.contributor.authorRaffield, Laura M.
dc.contributor.authorBrenes, Gretchen A.
dc.contributor.authorCox, Amanda J.
dc.contributor.authorFreedman, Barry I.
dc.contributor.authorHugenschmidt, Christina E.
dc.contributor.authorHsu, Fang-Chi
dc.contributor.authorXu, Jianzhao
dc.contributor.authorWagner, Benjamin C.
dc.contributor.authorWilliamson, Jeff D.
dc.contributor.authorMaldjian, Joseph A.
dc.contributor.authorBowden, Donald W.
dc.date.accessioned2017-06-20T00:22:21Z
dc.date.available2017-06-20T00:22:21Z
dc.date.issued2016
dc.identifier.issn1056-8727
dc.identifier.doi10.1016/j.jdiacomp.2015.09.010
dc.identifier.urihttp://hdl.handle.net/10072/340386
dc.description.abstractAims: Anxiety, depression, accelerated cognitive decline, and increased risk of dementia are observed in individuals with type 2 diabetes. Anxiety and depression may contribute to lower performance on cognitive tests and differences in neuroimaging observed in individuals with type 2 diabetes. Methods: These relationships were assessed in 655 European Americans with type 2 diabetes from 504 Diabetes Heart Study families. Participants completed cognitive testing, brain magnetic resonance imaging, the Brief Symptom Inventory Anxiety subscale, and the Center for Epidemiologic Studies Depression-10. Results: In analyses adjusted for age, sex, educational attainment, and use of psychotropic medications, individuals with comorbid anxiety and depression symptoms had lower performance on all cognitive testing measures assessed (p ≤ 0.005). Those with both anxiety and depression also had increased white matter lesion volume (p = 0.015), decreased gray matter cerebral blood flow (p = 4.43 × 10− 6), decreased gray matter volume (p = 0.002), increased white and gray matter mean diffusivity (p ≤ 0.001), and decreased white matter fractional anisotropy (p = 7.79 × 10− 4). These associations were somewhat attenuated upon further adjustment for health status related covariates. Conclusions: Comorbid anxiety and depression symptoms were associated with cognitive performance and brain structure in a European American cohort with type 2 diabetes.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom143
dc.relation.ispartofpageto149
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Diabetes and its Complications
dc.relation.ispartofvolume30
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1103
dc.titleAssociations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorCox, Amanda J.


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