dc.contributor.author | Raffield, Laura M. | |
dc.contributor.author | Brenes, Gretchen A. | |
dc.contributor.author | Cox, Amanda J. | |
dc.contributor.author | Freedman, Barry I. | |
dc.contributor.author | Hugenschmidt, Christina E. | |
dc.contributor.author | Hsu, Fang-Chi | |
dc.contributor.author | Xu, Jianzhao | |
dc.contributor.author | Wagner, Benjamin C. | |
dc.contributor.author | Williamson, Jeff D. | |
dc.contributor.author | Maldjian, Joseph A. | |
dc.contributor.author | Bowden, Donald W. | |
dc.date.accessioned | 2017-06-20T00:22:21Z | |
dc.date.available | 2017-06-20T00:22:21Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1056-8727 | |
dc.identifier.doi | 10.1016/j.jdiacomp.2015.09.010 | |
dc.identifier.uri | http://hdl.handle.net/10072/340386 | |
dc.description.abstract | Aims: Anxiety, depression, accelerated cognitive decline, and increased risk of dementia are observed in individuals with type 2 diabetes. Anxiety and depression may contribute to lower performance on cognitive tests and differences in neuroimaging observed in individuals with type 2 diabetes. Methods: These relationships were assessed in 655 European Americans with type 2 diabetes from 504 Diabetes Heart Study families. Participants completed cognitive testing, brain magnetic resonance imaging, the Brief Symptom Inventory Anxiety subscale, and the Center for Epidemiologic Studies Depression-10. Results: In analyses adjusted for age, sex, educational attainment, and use of psychotropic medications, individuals with comorbid anxiety and depression symptoms had lower performance on all cognitive testing measures assessed (p ≤ 0.005). Those with both anxiety and depression also had increased white matter lesion volume (p = 0.015), decreased gray matter cerebral blood flow (p = 4.43 × 10− 6), decreased gray matter volume (p = 0.002), increased white and gray matter mean diffusivity (p ≤ 0.001), and decreased white matter fractional anisotropy (p = 7.79 × 10− 4). These associations were somewhat attenuated upon further adjustment for health status related covariates. Conclusions: Comorbid anxiety and depression symptoms were associated with cognitive performance and brain structure in a European American cohort with type 2 diabetes. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 143 | |
dc.relation.ispartofpageto | 149 | |
dc.relation.ispartofissue | 1 | |
dc.relation.ispartofjournal | Journal of Diabetes and its Complications | |
dc.relation.ispartofvolume | 30 | |
dc.subject.fieldofresearch | Clinical Sciences not elsewhere classified | |
dc.subject.fieldofresearch | Clinical Sciences | |
dc.subject.fieldofresearchcode | 110399 | |
dc.subject.fieldofresearchcode | 1103 | |
dc.title | Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Cox, Amanda J. | |