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  • Toxicity evaluation of Xanthorrhoea johnsonii leaf methanolic extract using the Artemia franciscana bioassay

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    Author(s)
    Cock, IE
    Kalt, FR
    Griffith University Author(s)
    Cock, Ian E.
    Kalt, Fred R.
    Year published
    2010
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    Abstract
    The toxicity of Xanthorrhoea johnsonii methanolic leaf extract was investigated using the Artemia franciscana nauplii bioassay. At 24 h, the extract produced an EC 50 of 361.0 ᠴ1.8 姯ml, indicating that it was substantially more toxic than the pesticide Mevinphos (1346.2 ᠸ0.1 ?g/ml) and approximately 4 fold less toxic than potassium dichromate (87.1 ᠵ.2 姯ml). Whilst potassium dichromate LC 50 values remained constant across the 72-h test period, these values decreased for the extract and Mevinphos to similar values (199.8 ᠶ0.5 and 114 ᠱ2.8 姯ml, respectively), indicating their similar level of efficacy. Noteworthy was the ...
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    The toxicity of Xanthorrhoea johnsonii methanolic leaf extract was investigated using the Artemia franciscana nauplii bioassay. At 24 h, the extract produced an EC 50 of 361.0 ᠴ1.8 姯ml, indicating that it was substantially more toxic than the pesticide Mevinphos (1346.2 ᠸ0.1 ?g/ml) and approximately 4 fold less toxic than potassium dichromate (87.1 ᠵ.2 姯ml). Whilst potassium dichromate LC 50 values remained constant across the 72-h test period, these values decreased for the extract and Mevinphos to similar values (199.8 ᠶ0.5 and 114 ᠱ2.8 姯ml, respectively), indicating their similar level of efficacy. Noteworthy was the apparent anesthetic effect of X. johnsonii leaf extract. Although the extract initially appeared to kill the A. franciscana nauplii, they were seen to temporarily recover by 48 h only to die by 72 h.
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    Journal Title
    Pharmacognosy Magazine
    Volume
    6
    Issue
    23
    DOI
    https://doi.org/10.4103/0973-1296.66929
    Copyright Statement
    © 2010 Phcog.net. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Biological Sciences not elsewhere classified
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/34061
    Collection
    • Journal articles

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