Toxicity evaluation of Xanthorrhoea johnsonii leaf methanolic extract using the Artemia franciscana bioassay
Abstract
The toxicity of Xanthorrhoea johnsonii methanolic leaf extract was investigated using the Artemia franciscana nauplii bioassay. At 24 h, the extract produced an EC 50 of 361.0 ᠴ1.8 姯ml, indicating that it was substantially more toxic than the pesticide Mevinphos (1346.2 ᠸ0.1 ?g/ml) and approximately 4 fold less toxic than potassium dichromate (87.1 ᠵ.2 姯ml). Whilst potassium dichromate LC 50 values remained constant across the 72-h test period, these values decreased for the extract and Mevinphos to similar values (199.8 ᠶ0.5 and 114 ᠱ2.8 姯ml, respectively), indicating their similar level of efficacy. Noteworthy was the ...
View more >The toxicity of Xanthorrhoea johnsonii methanolic leaf extract was investigated using the Artemia franciscana nauplii bioassay. At 24 h, the extract produced an EC 50 of 361.0 ᠴ1.8 姯ml, indicating that it was substantially more toxic than the pesticide Mevinphos (1346.2 ᠸ0.1 ?g/ml) and approximately 4 fold less toxic than potassium dichromate (87.1 ᠵ.2 姯ml). Whilst potassium dichromate LC 50 values remained constant across the 72-h test period, these values decreased for the extract and Mevinphos to similar values (199.8 ᠶ0.5 and 114 ᠱ2.8 姯ml, respectively), indicating their similar level of efficacy. Noteworthy was the apparent anesthetic effect of X. johnsonii leaf extract. Although the extract initially appeared to kill the A. franciscana nauplii, they were seen to temporarily recover by 48 h only to die by 72 h.
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View more >The toxicity of Xanthorrhoea johnsonii methanolic leaf extract was investigated using the Artemia franciscana nauplii bioassay. At 24 h, the extract produced an EC 50 of 361.0 ᠴ1.8 姯ml, indicating that it was substantially more toxic than the pesticide Mevinphos (1346.2 ᠸ0.1 ?g/ml) and approximately 4 fold less toxic than potassium dichromate (87.1 ᠵ.2 姯ml). Whilst potassium dichromate LC 50 values remained constant across the 72-h test period, these values decreased for the extract and Mevinphos to similar values (199.8 ᠶ0.5 and 114 ᠱ2.8 姯ml, respectively), indicating their similar level of efficacy. Noteworthy was the apparent anesthetic effect of X. johnsonii leaf extract. Although the extract initially appeared to kill the A. franciscana nauplii, they were seen to temporarily recover by 48 h only to die by 72 h.
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Journal Title
Pharmacognosy Magazine
Volume
6
Issue
23
Copyright Statement
© 2010 Phcog.net. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Subject
Biological Sciences not elsewhere classified
Pharmacology and Pharmaceutical Sciences