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  • Comparison of Fluorinated and Nonfluorinated Lipids in Self-Adjuvanting Delivery Systems for Peptide-Based Vaccines

    Author(s)
    Hussein, Waleed M
    Mukaida, Saori
    Azmi, Fazren
    Bartlett, Stacey
    Olivier, Celine
    Batzloff, Michael R
    Good, Michael F
    Skwarczynski, Mariusz
    Toth, Istvan
    Griffith University Author(s)
    Good, Michael F.
    Year published
    2017
    Metadata
    Show full item record
    Abstract
    Safe immunostimulants (adjuvants) are essential for the development of highly potent peptide-based vaccines. This study examined for the first time whether fluorinated lipids could stimulate humoral immunity in vivo when conjugated to peptide antigen. The impact of fluorination on humoral immunity was tested using a library of peptide-based vaccine candidates against the group A streptococcus (GAS). The fluorinated constructs stimulated similar mouse IgG titers to those elicited by complete Freund’s adjuvant (CFA) and were higher than those produced in mice that received the nonfluorinated constructs.Safe immunostimulants (adjuvants) are essential for the development of highly potent peptide-based vaccines. This study examined for the first time whether fluorinated lipids could stimulate humoral immunity in vivo when conjugated to peptide antigen. The impact of fluorination on humoral immunity was tested using a library of peptide-based vaccine candidates against the group A streptococcus (GAS). The fluorinated constructs stimulated similar mouse IgG titers to those elicited by complete Freund’s adjuvant (CFA) and were higher than those produced in mice that received the nonfluorinated constructs.
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    Journal Title
    ACS Medicinal Chemistry Letters
    Volume
    8
    Issue
    2
    DOI
    https://doi.org/10.1021/acsmedchemlett.6b00453
    Subject
    Medicinal and biomolecular chemistry
    Organic chemistry
    Pharmacology and pharmaceutical sciences
    Pharmacology and pharmaceutical sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/340728
    Collection
    • Journal articles

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