Comparison of Fluorinated and Nonfluorinated Lipids in Self-Adjuvanting Delivery Systems for Peptide-Based Vaccines
Author(s)
Hussein, Waleed M
Mukaida, Saori
Azmi, Fazren
Bartlett, Stacey
Olivier, Celine
Batzloff, Michael R
Good, Michael F
Skwarczynski, Mariusz
Toth, Istvan
Griffith University Author(s)
Year published
2017
Metadata
Show full item recordAbstract
Safe immunostimulants (adjuvants) are essential for the development of highly potent peptide-based vaccines. This study examined for the first time whether fluorinated lipids could stimulate humoral immunity in vivo when conjugated to peptide antigen. The impact of fluorination on humoral immunity was tested using a library of peptide-based vaccine candidates against the group A streptococcus (GAS). The fluorinated constructs stimulated similar mouse IgG titers to those elicited by complete Freund’s adjuvant (CFA) and were higher than those produced in mice that received the nonfluorinated constructs.Safe immunostimulants (adjuvants) are essential for the development of highly potent peptide-based vaccines. This study examined for the first time whether fluorinated lipids could stimulate humoral immunity in vivo when conjugated to peptide antigen. The impact of fluorination on humoral immunity was tested using a library of peptide-based vaccine candidates against the group A streptococcus (GAS). The fluorinated constructs stimulated similar mouse IgG titers to those elicited by complete Freund’s adjuvant (CFA) and were higher than those produced in mice that received the nonfluorinated constructs.
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Journal Title
ACS Medicinal Chemistry Letters
Volume
8
Issue
2
Subject
Medicinal and biomolecular chemistry
Organic chemistry
Pharmacology and pharmaceutical sciences
Pharmacology and pharmaceutical sciences not elsewhere classified