Show simple item record

dc.contributor.authorKoenig, Maria
dc.contributor.authorEscher, Beate I
dc.contributor.authorNeale, Peta A
dc.contributor.authorKrauss, Martin
dc.contributor.authorHilscherova, Klara
dc.contributor.authorNovak, Jiri
dc.contributor.authorTeodorovic, Ivana
dc.contributor.authorSchulze, Tobias
dc.contributor.authorSeidensticker, Sven
dc.contributor.authorHashmi, Muhammad Arslan Kamal
dc.contributor.authorAhlheim, Joerg
dc.contributor.authorBrack, Werner
dc.date.accessioned2017-07-17T12:30:23Z
dc.date.available2017-07-17T12:30:23Z
dc.date.issued2017
dc.identifier.issn0269-7491
dc.identifier.doi10.1016/j.envpol.2016.11.011
dc.identifier.urihttp://hdl.handle.net/10072/340875
dc.description.abstractComplex mixtures of micropollutants, including pesticides, pharmaceuticals and industrial chemicals emitted by wastewater effluents to European rivers may compromise the quality of these water resources and may pose a risk to ecosystem health and abstraction of drinking water. In the present study, an integrated analytical and bioanalytical approach was applied to investigate the impact of untreated wastewater effluents from the city of Novi Sad, Serbia, into the River Danube. The study was based on three on-site large volume solid phase extracted water samples collected upstream and downstream of the untreated wastewater discharge. Chemical screening with liquid chromatography high resolution mass spectrometry (LC-HRMS) was applied together with a battery of in vitro cell-based bioassays covering important steps of the cellular toxicity pathway to evaluate effects on the activation of metabolism (arylhydrocarbon receptor AhR, peroxisome proliferator activated receptor gamma PPARγ), specific modes of action (estrogen receptor ERα, androgen receptor AR) and adaptive stress responses (oxidative stress, inflammation). Increased effects, significantly changed contamination patterns and higher chemical concentrations were observed downstream of the wastewater discharge. A mass balance approach showed that enhanced endocrine disruption was in good agreement with concentrations of detected hormones, while only a smaller fraction of the effects on xenobiotic metabolism (<1%) and adaptive stress responses (0–12%) could be explained by the detected chemicals. The chemical and effects patterns observed upstream of the discharge point were fairly re-established at about 7 km downstream, demonstrating the enormous dilution capacity of this large river.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom1220
dc.relation.ispartofpageto1230
dc.relation.ispartofissueB
dc.relation.ispartofjournalEnvironmental Pollution
dc.relation.ispartofvolume220
dc.relation.urihttp://purl.org/au-research/grants/NHMRC/APP1074775
dc.relation.grantIDAPP1074775
dc.relation.fundersNHMRC
dc.subject.fieldofresearchEnvironmental management
dc.subject.fieldofresearchSurface water quality processes and contaminated sediment assessment
dc.subject.fieldofresearchPollution and contamination not elsewhere classified
dc.subject.fieldofresearchcode410404
dc.subject.fieldofresearchcode410504
dc.subject.fieldofresearchcode410599
dc.titleImpact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorNeale, Peta A.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record