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  • Isolation and characterization of cytotoxic cyclotides from Viola tricolor

    Author
    Tang, Jun
    K. Wang, Conan
    Pan, Xulin
    Yan, He
    Zeng, Guangzhi
    Xu, Wenyan
    He, Wenjun
    Daly, Norelle L.
    J. Craik, David
    Tan, Ninghua
    Year published
    2010
    Metadata
    Show full item record
    Abstract
    Many plants of the Violaceae plant family have been used in traditional remedies, and these plants often contain cyclotides, a particular type of plant cyclopeptide that is distinguished by a cyclic cystine knot motif. In general, bioactive plant cyclopeptides are interesting candidates for drug development. In the current study, a suite of 14 cyclotides, which includes seven novel cyclotides [vitri B, C, D, E, F, varv Hm, and He], together with seven known cyclotides [varv A, D, E, F, H, vitri A, and cycloviolacin O2], was isolated from Viola tricolor, a common flower. A chromatography-based method was used to isolate the ...
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    Many plants of the Violaceae plant family have been used in traditional remedies, and these plants often contain cyclotides, a particular type of plant cyclopeptide that is distinguished by a cyclic cystine knot motif. In general, bioactive plant cyclopeptides are interesting candidates for drug development. In the current study, a suite of 14 cyclotides, which includes seven novel cyclotides [vitri B, C, D, E, F, varv Hm, and He], together with seven known cyclotides [varv A, D, E, F, H, vitri A, and cycloviolacin O2], was isolated from Viola tricolor, a common flower. A chromatography-based method was used to isolate the cyclotides, which were characterized using tandem mass spectrometry and NMR spectroscopy. Several of the cyclotides showed cytotoxic activities against five cancer cell lines, U251, MDA-MB-231, A549, DU145, and BEL-7402. Three cyclotides, vitri A, vitri F, and cycloviolacin O2, were the most cytotoxic. The cytotoxic activity of the cyclotides did not correlate well with their hemolytic activity, indicating that different interactions, most likely with membranes, are involved for cytotoxic and hemolytic activities. Homology modeling of the structures was used in deriving structure-activity relationships.
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    Journal Title
    Peptides
    Volume
    31
    Issue
    3
    DOI
    https://doi.org/10.1016/j.peptides.2010.05.004
    Subject
    Structural Biology (incl. Macromolecular Modelling)
    Publication URI
    http://hdl.handle.net/10072/34094
    Collection
    • Journal articles

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