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dc.contributor.authorGupta, B
dc.contributor.authorKumar, N
dc.contributor.authorJohnson, NW
dc.date.accessioned2018-06-13T01:00:24Z
dc.date.available2018-06-13T01:00:24Z
dc.date.issued2017
dc.identifier.issn1513-7368
dc.identifier.doi10.22034/APJCP.2017.18.2.347
dc.identifier.urihttp://hdl.handle.net/10072/341214
dc.description.abstractBackground: Squamous cell carcinomas of the upper aero-digestive tract (UADTSCC) are a multifaceted public health problem. Effects of lifestyle risk factors, including tobacco (chewing and smoking), alcohol drinking and exposure to second hand tobacco smoke (SHS) at home and their association with UADT cancers was assessed in a case-control study with a life-course perspective. The study was conducted at two different hospitals in Pune, India. Material and methods: The total sample size (N=480) included 240 histopathologically confirmed cases of UADT cancers and an equal number of controls frequency matched with cases by gender and age distribution (+5 years). All the patients were interviewed face-face using structured questionnaires. Self-reported information on socio-demographic and lifestyle risk factors from childhood to the date of diagnosis of disease/cancer was obtained. Frequency, duration and age of initiation of habits were also recorded to study dose-response relationships. Odds ratios and their 95% confidence intervals were calculated through unconditional logistic regression, adjusting for relevant potential confounders. Results: Chewing tobacco emerged as the strongest predictor for UADT cancers (OR=7.61; 95% CI 4.65-12.45) in comparison to smoking and drinking alcohol. Exposure to SHS during childhood (Conclusions: Early exposure to various modifiable lifestyle risk factors has a strong positive association with UADT cancer incidence. Effective future public health interventions with focus on vital time points in life targeting these risk factors could possibly be a major step in primary prevention and control of this cancer at the population level.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAsian Pacific Organization for Cancer Prevention
dc.relation.ispartofpagefrom347
dc.relation.ispartofpageto356
dc.relation.ispartofissue2
dc.relation.ispartofjournalAsian Pacific Journal of Cancer Prevention
dc.relation.ispartofvolume18
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchOncology and carcinogenesis not elsewhere classified
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode321199
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.titleRelationship of lifetime exposure to tobacco, alcohol and second hand tobacco smoke with upper aero-digestive tract cancers in India: A case-control study with a life-course perspective
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Health, School of Dentistry and Oral Health
gro.rights.copyright© The Author(s) 2017. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal’s website or contact the author[s].
gro.hasfulltextFull Text
gro.griffith.authorJohnson, Newell W.


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