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dc.contributor.authorSenadeera, Sarath PD
dc.contributor.authorDuffy, Sandra
dc.contributor.authorAvery, Vicky M
dc.contributor.authorCarroll, Anthony R
dc.date.accessioned2017-07-03T05:35:33Z
dc.date.available2017-07-03T05:35:33Z
dc.date.issued2017
dc.identifier.issn0960-894X
dc.identifier.doi10.1016/j.bmcl.2017.03.065
dc.identifier.urihttp://hdl.handle.net/10072/341226
dc.description.abstractChemical investigations of the MeOH extract of air dried flowers of the Australian tree Angophora woodsiana (Myrtaceae) yielded two new β-triketones, woodsianones A and B (1, 2) and nine known β-triketones (3–11). Woodsianone A is a β-triketone-sesquiterpene adduct and woodsianone B is a β-triketone epoxide derivative. The structures of the new and known compounds were elucidated from the analysis of 1D/2D NMR and MS data. The relative configurations of the compounds were determined from analysis of 1H–1H coupling constants and ROESY correlations. All compounds (1–11) had antiplasmodial activity against the chloroquine sensitive strain 3D7. The known compound rhodomyrtone (5) and new compound woodsianone B (2) showed moderate antiplasmodial activities against the 3D7 strain (1.84 µM and 3.00 µM, respectively) and chloroquine resistant strain Dd2 (4.00 µM and 2.53 µM, respectively).
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom2602
dc.relation.ispartofpageto2607
dc.relation.ispartofissue11
dc.relation.ispartofjournalBioorganic and Medicinal Chemistry Letters
dc.relation.ispartofvolume27
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchBiochemistry and cell biology not elsewhere classified
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode310199
dc.subject.fieldofresearchcode3214
dc.titleAntiplasmodial ß-triketones from the flowers of the Australian tree Angophora woodsiana
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, Griffith School of Environment
gro.hasfulltextNo Full Text
gro.griffith.authorCarroll, Anthony R.
gro.griffith.authorDuffy, Sandra
gro.griffith.authorAvery, Vicky M.


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