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  • Biomarkers of oxidative stress in pregnancy complications

    Author(s)
    Cuffe, James SM
    Xu, Ziheng Calvin
    Perkins, Anthony V
    Griffith University Author(s)
    Perkins, Anthony V.
    Xu, Calvin
    Cuffe, James S.
    Year published
    2017
    Metadata
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    Abstract
    Pregnancy complications including pre-eclampsia, gestational-diabetes mellitus, preterm birth and intrauterine growth restriction can cause acute and chronic health problems for the mother and lead to fetal loss or dysregulation of infant physiology. The human placenta is susceptible to oxidative stress and oxidative damage in early gestation contributes to the onset of these conditions later in pregnancy. Current methods of predicting pregnancy complications are limited and although a large number of factors are associated with disease progression, few biomarkers have been used to aid in disease diagnosis early in gestation. ...
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    Pregnancy complications including pre-eclampsia, gestational-diabetes mellitus, preterm birth and intrauterine growth restriction can cause acute and chronic health problems for the mother and lead to fetal loss or dysregulation of infant physiology. The human placenta is susceptible to oxidative stress and oxidative damage in early gestation contributes to the onset of these conditions later in pregnancy. Current methods of predicting pregnancy complications are limited and although a large number of factors are associated with disease progression, few biomarkers have been used to aid in disease diagnosis early in gestation. This review discusses the detection of oxidative stress markers in biological fluids and highlights the need for further studies to validate their use in the prediction or diagnosis of pregnancy disorders.
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    Journal Title
    Biomarkers in Medicine
    Volume
    11
    Issue
    3
    DOI
    https://doi.org/10.2217/bmm-2016-0250
    Subject
    Medicinal and biomolecular chemistry
    Medicinal and biomolecular chemistry not elsewhere classified
    Medical biochemistry and metabolomics
    Clinical sciences
    Publication URI
    http://hdl.handle.net/10072/341266
    Collection
    • Journal articles

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