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dc.contributor.authorDashti, Yousef
dc.contributor.authorGrkovic, Tanja
dc.contributor.authorAbdelmohsen, Usama Ramadan
dc.contributor.authorHentschel, Ute
dc.contributor.authorQuinn, Ronald J
dc.date.accessioned2017-07-04T04:32:33Z
dc.date.available2017-07-04T04:32:33Z
dc.date.issued2017
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/acs.jnatprod.6b00673
dc.identifier.urihttp://hdl.handle.net/10072/341311
dc.description.abstractThe metabolite profiles of three sponge-derived actinomycetes, namely, Micromonospora sp. RV43, Rhodococcus sp. RV157, and Actinokineospora sp. EG49 were investigated after elicitation with N-acetyl-d-glucosamine. 1H NMR fingerprint methodology was utilized to study the differences in the metabolic profiles of the bacterial extracts before and after elicitation. Our study found that the addition of N-acetyl-d-glucosamine modified the secondary metabolite profiles of the three investigated actinomycete isolates. N-Acetyl-d-glucosamine induced the production of 3-formylindole (11) and guaymasol (12) in Micromonospora sp. RV43, the siderophore bacillibactin 16, and surfactin antibiotic 17 in Rhodococcus sp. RV157 and increased the production of minor metabolites actinosporins E–H (21–24) in Actinokineospora sp. EG49. These results highlight the use of NMR fingerprinting to detect changes in metabolism following addition of N-acetyl-d-glucosamine. N-Acetyl-d-glucosamine was shown to have multiple effects including suppression of metabolites, induction of new metabolites, and increased production of minor compounds.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofpagefrom828
dc.relation.ispartofpageto836
dc.relation.ispartofissue4
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume80
dc.subject.fieldofresearchChemical Sciences not elsewhere classified
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode039999
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleActinomycete Metabolome Induction/Suppression with N-Acetylglucosamine
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorGrkovic, Tanja
gro.griffith.authorDashti, Yousef


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