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dc.contributor.authorShim, Kyu-Young
dc.contributor.authorLee, Dongwook
dc.contributor.authorHan, Jeonghun
dc.contributor.authorNam-Trung, Nguyen
dc.contributor.authorPark, Sungsu
dc.contributor.authorSung, Jong Hwan
dc.date.accessioned2017-07-06T02:00:02Z
dc.date.available2017-07-06T02:00:02Z
dc.date.issued2017
dc.identifier.issn1387-2176
dc.identifier.doi10.1007/s10544-017-0179-y
dc.identifier.urihttp://hdl.handle.net/10072/341315
dc.description.abstractCurrent in vitro gut models lack physiological relevance, and various approaches have been taken to improve current cell culture models. For example, mimicking the three-dimensional (3D) tissue structure or fluidic environment has been shown to improve the physiological function of gut cells. Here, we incorporated a collagen scaffold that mimics the human intestinal villi into a microfluidic device, thus providing cells with both 3D tissue structure and fluidic shear. We hypothesized that the combined effect of 3D structure and fluidic shear may provide cells with adequate stimulus to induce further differentiation and improve physiological relevance. The physiological function of our ‘3D gut chip’ was assessed by measuring the absorptive permeability of the gut epithelium and activity of representative enzymes, as well as morphological evaluation. Our results suggest that the combination of fluidic stimulus and 3D structure induces further improvement in gut functions. Our work provides insight into the effect of different tissue environment on gut cells.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofpagefrom37- 1
dc.relation.ispartofpageto37- 10
dc.relation.ispartofjournalBiomedical Microdevices
dc.relation.ispartofvolume19
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchBiomedical engineering not elsewhere classified
dc.subject.fieldofresearchMaterials engineering
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode400399
dc.subject.fieldofresearchcode4016
dc.titleMicrofluidic gut-on-a-chip with three-dimensional villi structure
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2017 Springer US. This is an electronic version of an article published in Biomedical Microdevices, 19:37, 2017. Biomedical Microdevices is available online at: http://link.springer.com/ with the open URL of your article.
gro.hasfulltextFull Text
gro.griffith.authorNguyen, Nam-Trung


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