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dc.contributor.authorLee, Alice MC
dc.contributor.authorAnderson, Paul H
dc.contributor.authorSawyer, Rebecca K
dc.contributor.authorMoore, Alison J
dc.contributor.authorForwood, Mark R
dc.contributor.authorSteck, Roland
dc.contributor.authorMorris, Howard A
dc.contributor.authorO'Loughlin, Peter D
dc.date.accessioned2017-05-03T12:07:13Z
dc.date.available2017-05-03T12:07:13Z
dc.date.issued2010
dc.date.modified2010-09-21T06:57:36Z
dc.identifier.issn0960-0760
dc.identifier.doi10.1016/j.jsbmb.2010.04.004
dc.identifier.urihttp://hdl.handle.net/10072/34154
dc.description.abstractWe have previously shown that vitamin D deficiency in young male rats results in significant reduction in femoral trabecular bone volume (BV/TV). However, the effects of vitamin D deficiency and its impact on other relevant skeletal sites remain unclear. Ten week old male Sprague-Dawley rats were fed various levels of vitamin D3 (2, 4, 8, and 12 IU/day) with standard Ca (0.4%) until 30 weeks of age and achieved stable serum 25-hydroxyvitamin D3 (25D) levels between 16 and 117 nmol/L. At time of death, femora, L2 vertebrae and tibiae were processed for bone histomorphometric analyses and tibial cortical strength by 3-point mechanical testing. A significant association between serum 25D and trabecular bone occurred for both the distal femoral metaphysis (R2=0.34, P<0.05) and L2 vertebrae (R2=0.24, P<0.05). Tibia mid-shaft cortical bone was not, however, changed in terms of total volume, periosteal surface or endosteal surface as a function of vitamin D status. Furthermore, no changes to mechanical and intrinsic properties of the cortices were observed. We conclude that cortical bone is maintained under conditions of vitamin D deficiency in preference to cancellous bone in young growing rats.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom284
dc.relation.ispartofpageto287
dc.relation.ispartofissue1-2
dc.relation.ispartofjournalThe Journal of Steroid Biochemistry and Molecular Biology
dc.relation.ispartofvolume121
dc.rights.retentionY
dc.subject.fieldofresearchAnalytical chemistry
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchEndocrinology
dc.subject.fieldofresearchcode3401
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode320208
dc.titleDiscordant effects of vitamin D deficiency in trabecular and cortical bone architecture and strength in growing rodents
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorForwood, Mark R.


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