dc.contributor.author | Lee, Alice MC | |
dc.contributor.author | Anderson, Paul H | |
dc.contributor.author | Sawyer, Rebecca K | |
dc.contributor.author | Moore, Alison J | |
dc.contributor.author | Forwood, Mark R | |
dc.contributor.author | Steck, Roland | |
dc.contributor.author | Morris, Howard A | |
dc.contributor.author | O'Loughlin, Peter D | |
dc.date.accessioned | 2017-05-03T12:07:13Z | |
dc.date.available | 2017-05-03T12:07:13Z | |
dc.date.issued | 2010 | |
dc.date.modified | 2010-09-21T06:57:36Z | |
dc.identifier.issn | 0960-0760 | |
dc.identifier.doi | 10.1016/j.jsbmb.2010.04.004 | |
dc.identifier.uri | http://hdl.handle.net/10072/34154 | |
dc.description.abstract | We have previously shown that vitamin D deficiency in young male rats results in significant reduction in femoral trabecular bone volume (BV/TV). However, the effects of vitamin D deficiency and its impact on other relevant skeletal sites remain unclear. Ten week old male Sprague-Dawley rats were fed various levels of vitamin D3 (2, 4, 8, and 12 IU/day) with standard Ca (0.4%) until 30 weeks of age and achieved stable serum 25-hydroxyvitamin D3 (25D) levels between 16 and 117 nmol/L. At time of death, femora, L2 vertebrae and tibiae were processed for bone histomorphometric analyses and tibial cortical strength by 3-point mechanical testing. A significant association between serum 25D and trabecular bone occurred for both the distal femoral metaphysis (R2=0.34, P<0.05) and L2 vertebrae (R2=0.24, P<0.05). Tibia mid-shaft cortical bone was not, however, changed in terms of total volume, periosteal surface or endosteal surface as a function of vitamin D status. Furthermore, no changes to mechanical and intrinsic properties of the cortices were observed. We conclude that cortical bone is maintained under conditions of vitamin D deficiency in preference to cancellous bone in young growing rats. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofstudentpublication | Y | |
dc.relation.ispartofpagefrom | 284 | |
dc.relation.ispartofpageto | 287 | |
dc.relation.ispartofissue | 1-2 | |
dc.relation.ispartofjournal | The Journal of Steroid Biochemistry and Molecular Biology | |
dc.relation.ispartofvolume | 121 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Analytical chemistry | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearch | Endocrinology | |
dc.subject.fieldofresearchcode | 3401 | |
dc.subject.fieldofresearchcode | 3101 | |
dc.subject.fieldofresearchcode | 320208 | |
dc.title | Discordant effects of vitamin D deficiency in trabecular and cortical bone architecture and strength in growing rodents | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2010 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Forwood, Mark R. | |