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dc.contributor.authorLymbury, Robynen_US
dc.contributor.authorMarino, Matthewen_US
dc.contributor.authorPerkins, Anthonyen_US
dc.date.accessioned2017-04-24T08:09:20Z
dc.date.available2017-04-24T08:09:20Z
dc.date.issued2010en_US
dc.date.modified2011-06-16T06:03:12Z
dc.identifier.issn16134125en_US
dc.identifier.doi10.1002/mnfr.201000012en_AU
dc.identifier.urihttp://hdl.handle.net/10072/34156
dc.description.abstractOxidative stress has been directly implicated in hypertension and myocardial remodelling, two pathologies fundamental to the development of chronic heart failure. Selenium (Se) can act directly and indirectly as an antioxidant and a lowered Se status leads to a higher risk of cardiovascular disease. This study examined the role of Se on the development of hypertension and subsequent progression to chronic heart failure in spontaneously hypertensive rats (SHR). Three dietary groups were studied: (i) Se-free; (ii) normal Se (50?姠Se/kg food); and (iii) high Se (1000?姠Se/kg food). Systolic blood pressure and echocardiography were used to detect cardiac changes in vivo. At study end, cardiac tissues were assayed for glutathione peroxidase activity, thioredoxin reductase activity, and protein carbonyls. The major finding of this study was the high heart failure-related mortality rate in SHRs fed an Se-free diet (70%). Normal and high levels of dietary Se resulted in higher survival rates of 78 and 100%, respectively. Furthermore, high dietary Se was clearly associated with lower levels of cardiac oxidative damage and increased antioxidant expression, as well as a reduction in disease severity and mortality in the SHR.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherWileyen_US
dc.publisher.placeGermanyen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto9en_US
dc.relation.ispartofjournalMolecular Nutrition & Food Researchen_US
dc.relation.ispartofvolume54en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classifieden_US
dc.subject.fieldofresearchcode060199en_US
dc.titleEffect of dietary selenium on the progression of heart failure in the ageing spontaneously hypertensive raten_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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