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dc.contributor.authorWahab, Huda A
dc.contributor.authorPham, Ngoc B
dc.contributor.authorMuhammad, Tengku S Tengku
dc.contributor.authorHooper, John NA
dc.contributor.authorQuinn, Ronald J
dc.date.accessioned2017-07-14T00:13:57Z
dc.date.available2017-07-14T00:13:57Z
dc.date.issued2017
dc.identifier.issn1660-3397
dc.identifier.doi10.3390/md15010006
dc.identifier.urihttp://hdl.handle.net/10072/341834
dc.description.abstractA study of the chemical constituents from the Australian Sponge Hyrtios digitatus has provided a perspective on the connection between the chemistry and biology of the puupehenones, a unique and unusual class of merosesquiterpenes. In this study, a new tetracyclic merosesquiterpene, 19-methoxy-9,15-ene-puupehenol (1) was isolated from the marine sponge Hyrtios digitatus along with the known 20-methoxy-9,15-ene-puupehenol (2). Their structures were elucidated on the basis of spectroscopic data (1H and 13C NMR) in combination with experimental electronic circular dichroism (ECD) data. Compounds 1 and 2 are active at 1.78 μM and 3.05 μM, respectively, on Scavenger Receptor-Class B Type 1 HepG2 (SR-B1 HepG2) stable cell lines, targeting atherosclerosis disease.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherM D P I AG
dc.relation.ispartofpagefrom6-1
dc.relation.ispartofpageto6-10
dc.relation.ispartofissue1
dc.relation.ispartofjournalMarine Drugs
dc.relation.ispartofvolume15
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences not elsewhere classified
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode111599
dc.subject.fieldofresearchcode1115
dc.titleMerosesquiterpene Congeners from the Australian Sponge Hyrtios digitatus as Potential Drug Leads for Atherosclerosis Disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionPublished
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.rights.copyright© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
gro.hasfulltextFull Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorPham, Ngoc B.
gro.griffith.authorHooper, John N.
gro.griffith.authorAbdul Wahab, Nurul Huda H.


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