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dc.contributor.authorAbdul Wahab, Nurul Huda
dc.contributor.authorPham, Ngoc
dc.contributor.authorMuhammad, Tengku S. Tengku
dc.contributor.authorHooper, John
dc.contributor.authorQuinn, Ronald
dc.date.accessioned2017-07-14T00:13:57Z
dc.date.available2017-07-14T00:13:57Z
dc.date.issued2017
dc.identifier.issn1660-3397en_US
dc.identifier.doi10.3390/md15010006en_US
dc.identifier.urihttp://hdl.handle.net/10072/341834
dc.description.abstractA study of the chemical constituents from the Australian Sponge Hyrtios digitatus has provided a perspective on the connection between the chemistry and biology of the puupehenones, a unique and unusual class of merosesquiterpenes. In this study, a new tetracyclic merosesquiterpene, 19-methoxy-9,15-ene-puupehenol (1) was isolated from the marine sponge Hyrtios digitatus along with the known 20-methoxy-9,15-ene-puupehenol (2). Their structures were elucidated on the basis of spectroscopic data (1H and 13C NMR) in combination with experimental electronic circular dichroism (ECD) data. Compounds 1 and 2 are active at 1.78 μM and 3.05 μM, respectively, on Scavenger Receptor-Class B Type 1 HepG2 (SR-B1 HepG2) stable cell lines, targeting atherosclerosis disease.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherM D P I AGen_US
dc.relation.ispartofpagefrom6-1en_US
dc.relation.ispartofpageto6-10en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalMarine Drugsen_US
dc.relation.ispartofvolume15en_US
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode111599en_US
dc.titleMerosesquiterpene Congeners from the Australian Sponge Hyrtios digitatus as Potential Drug Leads for Atherosclerosis Diseaseen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.description.versionPublisheden_US
gro.facultyGriffith Sciences, Griffith Institute for Drug Discoveryen_US
gro.rights.copyright© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
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