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  • A potential role for GPR55 in the regulation of energy homeostasis

    Author(s)
    Simcocks, Anna C
    O'Keefe, Lannie
    Jenkin, Kayte A
    Mathai, Michael L
    Hryciw, Deanne H
    McAinch, Andrew J
    Griffith University Author(s)
    Skelly, Deanne
    Year published
    2014
    Metadata
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    Abstract
    G protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor that is expressed in several tissues involved in regulating energy homeostasis, including the hypothalamus, gastrointestinal tract, pancreas, liver, white adipose and skeletal muscle. GPR55 has been shown to have a role in cancer and gastrointestinal inflammation, as well as in obesity and type 2 diabetes mellitus (T2DM). Despite this,the (patho)physiological role of GPR55 in cell dysfunction is still poorly understood, largely because of the limited identification of downstream signalling targets. Nonetheless, research has suggested that GPR55 modulation ...
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    G protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor that is expressed in several tissues involved in regulating energy homeostasis, including the hypothalamus, gastrointestinal tract, pancreas, liver, white adipose and skeletal muscle. GPR55 has been shown to have a role in cancer and gastrointestinal inflammation, as well as in obesity and type 2 diabetes mellitus (T2DM). Despite this,the (patho)physiological role of GPR55 in cell dysfunction is still poorly understood, largely because of the limited identification of downstream signalling targets. Nonetheless, research has suggested that GPR55 modulation would be a useful pharmacological target in metabolically active tissues to improve treatment of diseases such as obesity and T2DM. Further research is essential to gain a better understanding of the role that this receptor might have in these and other pathophysiological conditions.
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    Journal Title
    Drug Discovery Today
    Volume
    19
    Issue
    8
    DOI
    https://doi.org/10.1016/j.drudis.2013.12.005
    Subject
    Biochemistry and cell biology
    Pharmacology and pharmaceutical sciences
    Pharmacology and pharmaceutical sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/341916
    Collection
    • Journal articles

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