A potential role for GPR55 in the regulation of energy homeostasis
Author(s)
Simcocks, Anna C
O'Keefe, Lannie
Jenkin, Kayte A
Mathai, Michael L
Hryciw, Deanne H
McAinch, Andrew J
Griffith University Author(s)
Year published
2014
Metadata
Show full item recordAbstract
G protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor that is expressed in several
tissues involved in regulating energy homeostasis, including the hypothalamus, gastrointestinal tract,
pancreas, liver, white adipose and skeletal muscle. GPR55 has been shown to have a role in cancer and
gastrointestinal inflammation, as well as in obesity and type 2 diabetes mellitus (T2DM). Despite this,the
(patho)physiological role of GPR55 in cell dysfunction is still poorly understood, largely because of the
limited identification of downstream signalling targets. Nonetheless, research has suggested that GPR55
modulation ...
View more >G protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor that is expressed in several tissues involved in regulating energy homeostasis, including the hypothalamus, gastrointestinal tract, pancreas, liver, white adipose and skeletal muscle. GPR55 has been shown to have a role in cancer and gastrointestinal inflammation, as well as in obesity and type 2 diabetes mellitus (T2DM). Despite this,the (patho)physiological role of GPR55 in cell dysfunction is still poorly understood, largely because of the limited identification of downstream signalling targets. Nonetheless, research has suggested that GPR55 modulation would be a useful pharmacological target in metabolically active tissues to improve treatment of diseases such as obesity and T2DM. Further research is essential to gain a better understanding of the role that this receptor might have in these and other pathophysiological conditions.
View less >
View more >G protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor that is expressed in several tissues involved in regulating energy homeostasis, including the hypothalamus, gastrointestinal tract, pancreas, liver, white adipose and skeletal muscle. GPR55 has been shown to have a role in cancer and gastrointestinal inflammation, as well as in obesity and type 2 diabetes mellitus (T2DM). Despite this,the (patho)physiological role of GPR55 in cell dysfunction is still poorly understood, largely because of the limited identification of downstream signalling targets. Nonetheless, research has suggested that GPR55 modulation would be a useful pharmacological target in metabolically active tissues to improve treatment of diseases such as obesity and T2DM. Further research is essential to gain a better understanding of the role that this receptor might have in these and other pathophysiological conditions.
View less >
Journal Title
Drug Discovery Today
Volume
19
Issue
8
Subject
Biochemistry and cell biology
Pharmacology and pharmaceutical sciences
Pharmacology and pharmaceutical sciences not elsewhere classified