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dc.contributor.authorSimcocks, Anna C
dc.contributor.authorO'Keefe, Lannie
dc.contributor.authorJenkin, Kayte A
dc.contributor.authorMathai, Michael L
dc.contributor.authorHryciw, Deanne H
dc.contributor.authorMcAinch, Andrew J
dc.date.accessioned2017-07-17T05:04:11Z
dc.date.available2017-07-17T05:04:11Z
dc.date.issued2014
dc.identifier.issn1359-6446
dc.identifier.doi10.1016/j.drudis.2013.12.005
dc.identifier.urihttp://hdl.handle.net/10072/341916
dc.description.abstractG protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor that is expressed in several tissues involved in regulating energy homeostasis, including the hypothalamus, gastrointestinal tract, pancreas, liver, white adipose and skeletal muscle. GPR55 has been shown to have a role in cancer and gastrointestinal inflammation, as well as in obesity and type 2 diabetes mellitus (T2DM). Despite this,the (patho)physiological role of GPR55 in cell dysfunction is still poorly understood, largely because of the limited identification of downstream signalling targets. Nonetheless, research has suggested that GPR55 modulation would be a useful pharmacological target in metabolically active tissues to improve treatment of diseases such as obesity and T2DM. Further research is essential to gain a better understanding of the role that this receptor might have in these and other pathophysiological conditions.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom1145
dc.relation.ispartofpageto1151
dc.relation.ispartofissue8
dc.relation.ispartofjournalDrug Discovery Today
dc.relation.ispartofvolume19
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences not elsewhere classified
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3214
dc.subject.fieldofresearchcode321499
dc.titleA potential role for GPR55 in the regulation of energy homeostasis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSkelly, Deanne


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