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dc.contributor.authorO'Keefe, L
dc.contributor.authorSimcocks, AC
dc.contributor.authorHryciw, DH
dc.contributor.authorMathai, ML
dc.contributor.authorMcAinch, AJ
dc.date.accessioned2017-07-17T05:05:09Z
dc.date.available2017-07-17T05:05:09Z
dc.date.issued2014
dc.identifier.issn1462-8902
dc.identifier.doi10.1111/dom.12144
dc.identifier.urihttp://hdl.handle.net/10072/341917
dc.description.abstractEvidence from in vitro and in vivo studies has demonstrated the deleterious pathological effects of a dysregulated endocannabinoid system. Increased stimulation of the cannabinoid receptor 1 (CB1) and subsequent downstream cellular signalling are both causative in the deleterious pathological effects observed in a number of diseases. When the CB1 cell signalling cascade is blocked, this results in whole body weight-loss, leading to a reduction in obesity and associated co-morbidities. In the central nervous system; however, CB1 antagonism results in adverse psychological side effects. Blockade of CB1 via peripheral acting compounds that do not cross the blood–brain barrier have been determined to have beneficial effects in metabolic tissues such as the liver and skeletal muscle. These results support the notion that peripheral blockade of CB1 using pharmacological antagonists is a viable target for the treatment of the current epidemic of obesity and its associated co-morbidities.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing Ltd.
dc.relation.ispartofpagefrom294
dc.relation.ispartofpageto304
dc.relation.ispartofissue4
dc.relation.ispartofjournalDiabetes, Obesity and Metabolism
dc.relation.ispartofvolume16
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1103
dc.titleThe cannabinoid receptor 1 and its role in influencing peripheral metabolism
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSkelly, Deanne


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