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dc.contributor.authorCornall, Lauren M
dc.contributor.authorMathai, Michael L
dc.contributor.authorHryciw, Deanne H
dc.contributor.authorMcAinch, Andrew J
dc.date.accessioned2017-07-17T05:06:07Z
dc.date.available2017-07-17T05:06:07Z
dc.date.issued2014
dc.identifier.issn1359-6446
dc.identifier.doi10.1016/j.drudis.2013.11.021
dc.identifier.urihttp://hdl.handle.net/10072/341918
dc.description.abstractObesity, type 2 diabetes mellitus and cardiovascular disease are at epidemic proportions in developed nations globally, representing major causes of ill-health and premature death. The search for drug targets to counter the growing prevalence of metabolic diseases has uncovered G-protein-coupled receptor 120 (GPR120). GPR120 agonism has been shown to improve inflammation and metabolic health on a systemic level via regulation of adiposity, gastrointestinal peptide secretion, taste preference and glucose homeostasis. Therefore, GPR120 agonists present as a novel therapeutic option that could be exploited for the treatment of impaired metabolic health. This review summarizes the current knowledge of GPR120 functionality and the potential applications of GPR120-specific agonists for the treatment of disease states such as obesity, type 2 diabetes mellitus and cardiovascular disease.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom670
dc.relation.ispartofpageto679
dc.relation.ispartofissue5
dc.relation.ispartofjournalDrug Discovery Today
dc.relation.ispartofvolume19
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences not elsewhere classified
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3214
dc.subject.fieldofresearchcode321499
dc.titleGPR120 agonism as a countermeasure against metabolic diseases
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSkelly, Deanne


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