Show simple item record

dc.contributor.authorCornall, Lauren M
dc.contributor.authorMathai, Michael L
dc.contributor.authorHryciw, Deanne H
dc.contributor.authorMcAinch, Andrew J
dc.date.accessioned2017-07-17T05:44:10Z
dc.date.available2017-07-17T05:44:10Z
dc.date.issued2013
dc.identifier.issn1420-682X
dc.identifier.doi10.1007/s00018-013-1419-9
dc.identifier.urihttp://hdl.handle.net/10072/341921
dc.description.abstractGPR43 is a receptor for short-chain fatty acids. Preliminary data suggest a putative role for GPR43 in regulating systemic health via processes including inflammation, carcinogenesis, gastrointestinal function, and adipogenesis. GPR43 is involved in secretion of gastrointestinal peptides, which regulate appetite and gastrointestinal motility. This suggests GPR43 may have a role in weight control. Moreover, GPR43 regulates plasma lipid profile and inflammatory processes, which further indicates that GPR43 could have the ability to modulate the etiology and pathogenesis of metabolic diseases such as obesity, type 2 diabetes mellitus, and cardiovascular disease. This review summarizes the current evidence regarding the ability of GPR43 to mediate both systemic and tissue specific functions and how GPR43 may be modulated in the treatment of metabolic disease.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherSpringer
dc.relation.ispartofpagefrom4759
dc.relation.ispartofpageto4770
dc.relation.ispartofissue24
dc.relation.ispartofjournalCellular and Molecular Life Sciences
dc.relation.ispartofvolume70
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchClinical sciences not elsewhere classified
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode320299
dc.titleThe therapeutic potential of GPR43: A novel role in modulating metabolic health
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSkelly, Deanne


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record