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dc.contributor.authorCornall, Lauren M
dc.contributor.authorMathai, Michael L
dc.contributor.authorHryciw, Deanne H
dc.contributor.authorMcAinch, Andrew J
dc.date.accessioned2017-07-17T05:55:35Z
dc.date.available2017-07-17T05:55:35Z
dc.date.issued2011
dc.identifier.issn1015-8987
dc.identifier.doi10.1159/000335820
dc.identifier.urihttp://hdl.handle.net/10072/341928
dc.description.abstractBackground/Aims: GPR43 and GPR120 have recently been deorphanised as receptors for fatty acids. Fatty acids mediate a variety of metabolic processes in the body, however, the effect these receptors have on metabolism is not fully understood. Here, we characterise the effect of diet-induced obesity on the expression of GPR43 and GPR120 in tissues important in maintaining metabolic health. Methods: Six-week old male Sprague Dawley rats were fed either a high fat diet (HFD; 22% fat) or control diet (5% fat; n = 8-9/group) for 12 weeks. Rats were euthanized and the heart, liver, soleus and extensor digitorum longus (EDL) skeletal muscles were excised. GPR43 and GPR120 receptor abundance was quantified by ‘real-time’ PCR. Results: GPR43 mRNA abundance was significantly up-regulated by a HFD in liver and soleus and EDL skeletal muscles compared to control (p ≤ 0.05). Whilst a HFD significantly up-regulated GPR120 gene transcripts in cardiac tissue and EDL skeletal muscle when compare to control (p ≤ 0.05). Conclusion: We have shown for the first time that up-regulation of GPR43 and GPR120 in response to a HFD, is tissue specific. This suggests these receptors have different roles in mediating metabolic function in a number of tissues in the human body.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherS. Karger AG
dc.relation.ispartofpagefrom949
dc.relation.ispartofpageto958
dc.relation.ispartofissue5
dc.relation.ispartofjournalCellular Physiology and Biochemistry
dc.relation.ispartofvolume28
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchMedical physiology not elsewhere classified
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3208
dc.subject.fieldofresearchcode320899
dc.titleDiet-induced obesity up-regulates the abundance of GPR43 and GPR120 in a tissue specific manner
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSkelly, Deanne


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