Show simple item record

dc.contributor.authorBosker, Thijs
dc.contributor.authorSantoro, Giacomo
dc.contributor.authorMelvin, Steven D
dc.date.accessioned2017-07-18T01:11:04Z
dc.date.available2017-07-18T01:11:04Z
dc.date.issued2017
dc.identifier.issn0045-6535
dc.identifier.doi10.1016/j.chemosphere.2017.05.063
dc.identifier.urihttp://hdl.handle.net/10072/342025
dc.description.abstractThe influence of salinity on toxicity outcomes has been demonstrated for various contaminants, but has received limited attention for endocrine disrupting chemicals (EDCs). Short-term laboratory tests using small-bodied fish are an important tool for evaluating impacts of EDCs on reproduction. Tests have been developed for both freshwater and estuarine/marine species, providing an opportunity to assess whether concentrations at which small-bodied fish respond to EDCs may be influenced by salinity. We conducted a semi-quantitative review of short-term laboratory tests with small-bodied fish exposed to EDCs, including 59 studies under freshwater conditions (7 species) and 23 studies conducted under saline conditions (5 species). We focused on two model estrogens [17α-ethinylestradiol and 17β-estradiol (E2)], and three androgens (17β-trenbolone, 5α-dihydrotestosterone and 17α-methyltestosterone). The lowest observed adverse effect concentration (LOAECLOW) for key reproductive endpoints was recorded, including sex-steroid and vitellogenin (VTG) levels, fecundity and fertilization. In 65.2% of cases, responses occurred at lower doses under freshwater compared to saline conditions, compared to only 4.3% of cases where fish responded to lower doses under saline conditions. The potential influence of salinity was more pronounced when estrogenic compounds were considered separately, with fish responding to lower doses under fresh compared to saline conditions in 90.5% of cases. Fecundity and E2 level were identified as the most sensitive endpoints for evaluating EDCs regardless of salinity. Interestingly, female VTG levels were a sensitive endpoint under freshwater but not saline conditions. Overall, our results suggest that salinity may be an important factor influencing how small-bodied fish respond to environmental EDCs.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom186
dc.relation.ispartofpageto196
dc.relation.ispartofjournalChemosphere
dc.relation.ispartofvolume183
dc.subject.fieldofresearchMarine and Estuarine Ecology (incl. Marine Ichthyology)
dc.subject.fieldofresearchcode060205
dc.titleSalinity and sensitivity to endocrine disrupting chemicals: A comparison of reproductive endpoints in small-bodied fish exposed under different salinities
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorMelvin, Steve D.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record