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dc.contributor.authorPawlak, Joannaen_US
dc.contributor.authorP. Mackessy, Stephenen_US
dc.contributor.authorM. Sixberry, Nicoleen_US
dc.contributor.authorA. Stura, Enricoen_US
dc.contributor.authorLe Du, Marie Heleneen_US
dc.contributor.authorMenez, Reneeen_US
dc.contributor.authorFoo, Chun Shinen_US
dc.contributor.authorMenez, Andreen_US
dc.contributor.authorNirthanan, Selvanayagamen_US
dc.contributor.authorManjunatha Kini, R.en_US
dc.date.accessioned2017-05-03T15:28:59Z
dc.date.available2017-05-03T15:28:59Z
dc.date.issued2009en_US
dc.date.modified2010-09-27T06:53:42Z
dc.identifier.issn08926638en_US
dc.identifier.doi10.1096/fj.08-113555en_AU
dc.identifier.urihttp://hdl.handle.net/10072/34242
dc.description.abstractA novel heterodimeric three-finger neurotoxin, irditoxin, was isolated from venom of the brown treesnake Boiga irregularis (Colubridae). Irditoxin subunit amino acid sequences were determined by Edman degradation and cDNA sequencing. The crystal structure revealed two subunits with a three-finger protein fold, typical for "nonconventional" toxins such as denmotoxin, bucandin, and candoxin. This is the first colubrid three-finger toxin dimer, covalently connected via an interchain disulfide bond. Irditoxin showed taxon-specific lethality toward birds and lizards and was nontoxic toward mice. It produced a potent neuromuscular blockade at the avian neuromuscular junction (IC(50)=10 nM), comparable to alpha-bungarotoxin, but was three orders of magnitude less effective at the mammalian neuromuscular junction. Covalently linked heterodimeric three-finger toxins found in colubrid venoms constitute a new class of venom peptides, which may be a useful source of new neurobiology probes and therapeutic leads.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherFederation of American Societies for Experimental Biologyen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom534en_US
dc.relation.ispartofpageto545en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalThe FASEB Journalen_US
dc.relation.ispartofvolume23en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchToxicology (incl. Clinical Toxicology)en_US
dc.subject.fieldofresearchBasic Pharmacologyen_US
dc.subject.fieldofresearchcode111506en_US
dc.subject.fieldofresearchcode111501en_US
dc.titleIrditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicityen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2009 Federation of American Societies for Experimental Biology. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.en_AU
gro.date.issued2009
gro.hasfulltextNo Full Text


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