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dc.contributor.authorEssop, M.en_US
dc.contributor.authorAnna Chan, W.en_US
dc.contributor.authorValle, A.en_US
dc.contributor.authorGarcía-Palmer, F.en_US
dc.contributor.authorDu Toit, E.en_US
dc.date.accessioned2017-05-03T15:31:43Z
dc.date.available2017-05-03T15:31:43Z
dc.date.issued2009en_US
dc.date.modified2010-10-04T06:53:54Z
dc.identifier.issn17481708en_US
dc.identifier.doi10.1111/j.1748-1716.2009.02024.xen_AU
dc.identifier.urihttp://hdl.handle.net/10072/34247
dc.description.abstractAim: Obesity is a major contributor to the global burden of disease and is closely associated with the development of type 2 diabetes and cardiovascular diseases. This study tested the hypothesis that mitochondrial respiratory capacity of the pre-diabetic heart is decreased leading to impaired contractile function and tolerance to ischaemia/reperfusion. Methods: Eight-week-old male Wistar rats were fed a high caloric diet for 16 weeks after which anthropometric, metabolic, cardiac and mitochondrial parameters were evaluated vs. age-matched lean controls. Cardiac function (working heart perfusions) and mitochondrial respiratory capacity were assessed at baseline and in response to acute oxygen deprivation. Results: Rats fed the high caloric diet exhibited increased body weight and visceral fat vs. the control group. Heart weights of obese rats were also increased. Triglyceride, fasting plasma insulin and free fatty acid levels were elevated, while high-density lipoprotein cholesterol levels were reduced in the obese group. Contractile function was attenuated at baseline and further decreased after subjecting hearts to ischaemia-reperfusion. Myocardial infarct sizes were increased while ADP phosphorylation rates were diminished in obese rats. However, no differences were found for mtDNA levels and the degree of oxidative stress-induced damage. Conclusions: These data show that decreased mitochondrial bioenergetic capacity in pre-diabetic rat hearts may impair respiratory capacity and reduce basal contractile function and tolerance to acute oxygen deprivation. Keywords metabolic syndrome, mitochondrial respiration, myocardial infarction, obesity.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent195955 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherWiley-Blackwell Publishingen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom289en_US
dc.relation.ispartofpageto296en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalActa Physiologicaen_US
dc.relation.ispartofvolume197en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchPhysiology not elsewhere classifieden_US
dc.subject.fieldofresearchcode060699en_US
dc.titleImpaired contractile function and mitochondrial respiratory capacity in response to oxygen deprivation in a rat model of pre-diabetesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightAuthor Posting. Copyright 2009 The Authors. This is the author's version of the work. It is posted here for personal use, not for redistribution. The definitive version was published in Acta Physiologica, Volume 197, Issue 4,289-296, 10.1111/j.1748-1716.2009.02024.xen_AU
gro.date.issued2009
gro.hasfulltextFull Text


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