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dc.contributor.authorMak, Elijah
dc.contributor.authorSu, Li
dc.contributor.authorWilliams, Guy B
dc.contributor.authorFirbank, Michael J
dc.contributor.authorLawson, Rachael A
dc.contributor.authorYarnall, Alison J
dc.contributor.authorDuncan, Gordon W
dc.contributor.authorMollenhauer, Brit
dc.contributor.authorOwen, Adrian M
dc.contributor.authorKhoo, Tien K
dc.contributor.authorBrooks, David J
dc.contributor.authorRowe, James B
dc.contributor.authorBarker, Roger A
dc.contributor.authorBurn, David J
dc.contributor.authorO'Brien, John T
dc.date.accessioned2017-10-31T12:31:31Z
dc.date.available2017-10-31T12:31:31Z
dc.date.issued2017
dc.identifier.issn0197-4580
dc.identifier.doi10.1016/j.neurobiolaging.2017.03.012
dc.identifier.urihttp://hdl.handle.net/10072/342673
dc.description.abstractWe investigated whole-brain atrophy and ventricular enlargement over 18 months in nondemented Parkinson's disease (PD) and examined their associations with clinical measures and baseline CSF markers. PD subjects (n = 100) were classified at baseline into those with mild cognitive impairment (MCI; PD-MCI, n = 36) and no cognitive impairment (PD-NC, n = 64). Percentage of whole-brain volume change (PBVC) and ventricular expansion over 18 months were assessed with FSL-SIENA and ventricular enlargement (VIENA) respectively. PD-MCI showed increased global atrophy (−1.1% ± 0.8%) and ventricular enlargement (6.9 % ± 5.2%) compared with both PD-NC (PBVC: −0.4 ± 0.5, p < 0.01; VIENA: 2.1% ± 4.3%, p < 0.01) and healthy controls. In a subset of 35 PD subjects, CSF levels of tau, and Aβ42/Aβ40 ratio were correlated with PBVC and ventricular enlargement respectively. The sample size required to demonstrate a 20% reduction in PBVC and VIENA was approximately 1/15th of that required to detect equivalent changes in cognitive decline. These findings suggest that longitudinal MRI measurements have potential to serve as surrogate markers to complement clinical assessments for future disease-modifying trials in PD.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom78
dc.relation.ispartofpageto90
dc.relation.ispartofjournalNeurobiology of Aging
dc.relation.ispartofvolume55
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1109
dc.titleLongitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorKhoo, Tien Kheng


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