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dc.contributor.authorDissanayaka, Nadeeka NW
dc.contributor.authorLawson, Rachael A
dc.contributor.authorYarnall, Alison J
dc.contributor.authorDuncan, Gordon W
dc.contributor.authorBreen, David P
dc.contributor.authorKhoo, Tien K
dc.contributor.authorBarker, Roger A
dc.contributor.authorBurn, David J
dc.date.accessioned2017-07-27T23:13:37Z
dc.date.available2017-07-27T23:13:37Z
dc.date.issued2017
dc.identifier.issn1353-8020
dc.identifier.doi10.1016/j.parkreldis.2017.01.001
dc.identifier.urihttp://hdl.handle.net/10072/342699
dc.description.abstractIntroduction: Anxiety and mild cognitive impairment (MCI) are prevalent non-motor manifestations of Parkinson's disease (PD). While few studies have demonstrated a possible link between cognitive dysfunction and anxiety in PD, to our knowledge, no studies have directly examined the association between them. This study investigated the association between anxiety and cognitive deficits in newly diagnosed PD patients. Methods: Patients with newly diagnosed PD (N ¼ 185) were recruited from community and outpatient clinics. Anxiety was assessed using the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) clinician rated anxiety item, which has previously been validated against a standardized criteria for the diagnosis of anxiety disorders in PD. Participants scoring 2 were classified as anxious. A threshold of 1 SD below normative values (obtained from controls) was used to define cognitive impairment. Impairments in specific cognitive domains were identified as being >1 SD below controls in 1 test per domain. Results: After controlling for age, education and motor severity, patients with anxiety were three times more likely to have cognitive impairment compared to those without anxiety (OR ¼ 3.0, 95% CI ¼ 1.2e7.3, p < 0.05). Patients with anxiety were more than twice as likely to be classified as having cognitive impairment due to impairment in the memory domain compared with PD without anxiety (OR ¼ 2.3, 95% CI ¼ 1.0e5.1, p < 0.05), whilst no associations were found between anxiety and performance on other cognitive domains. Conclusion: This study shows an association between anxiety and cognitive impairment (specifically memory impairment). Examining the neural basis of this association warrants future research in this developing field.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom63
dc.relation.ispartofpageto68
dc.relation.ispartofjournalParkinsonism & Related Disorders
dc.relation.ispartofvolume36
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1702
dc.titleAnxiety is associated with cognitive impairment in newly-diagnosed Parkinson's disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2017. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorKhoo, Tien Kheng


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