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  • Bacterial exopolysaccharides: Biosynthesis pathways and engineering strategies

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    SchmidPUB2990.pdf (3.246Mb)
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    Author(s)
    Schmid, Jochen
    Sieber, Volker
    Rehm, Bernd
    Griffith University Author(s)
    Rehm, Bernd
    Year published
    2015
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    Abstract
    Bacteria produce a wide range of exopolysaccharides which are synthesized via different biosynthesis pathways. The genes responsible for synthesis are often clustered within the genome of the respective production organism. A better understanding of the fundamental processes involved in exopolysaccharide biosynthesis and the regulation of these processes is critical toward genetic, metabolic and protein-engineering approaches to produce tailor-made polymers. These designer polymers will exhibit superior material properties targeting medical and industrial applications. Exploiting the natural design space for production of a ...
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    Bacteria produce a wide range of exopolysaccharides which are synthesized via different biosynthesis pathways. The genes responsible for synthesis are often clustered within the genome of the respective production organism. A better understanding of the fundamental processes involved in exopolysaccharide biosynthesis and the regulation of these processes is critical toward genetic, metabolic and protein-engineering approaches to produce tailor-made polymers. These designer polymers will exhibit superior material properties targeting medical and industrial applications. Exploiting the natural design space for production of a variety of biopolymer will open up a range of new applications. Here, we summarize the key aspects of microbial exopolysaccharide biosynthesis and highlight the latest engineering approaches toward the production of tailor-made variants with the potential to be used as valuable renewable and high-performance products for medical and industrial applications.
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    Journal Title
    Frontiers in Microbiology
    Volume
    6
    DOI
    https://doi.org/10.3389/fmicb.2015.00496
    Copyright Statement
    © 2015 Schmid, Sieber and Rehm. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
    Subject
    Soil sciences
    Microbiology
    Microbiology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/342775
    Collection
    • Journal articles

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