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  • Bioengineering towards self-assembly of particulate vaccines

    Author(s)
    Rehm, Bernd HA
    Griffith University Author(s)
    Rehm, Bernd
    Year published
    2017
    Metadata
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    Abstract
    There is an unmet demand for safe and efficient vaccines for prevention of various infectious diseases. Subunit vaccines comprise selected pathogen specific antigens are a safe alternative to whole organism vaccines. However they often lack immunogenicity. Natural and synthetic self-assembling polymers and proteins will be reviewed in view their use to encapsulate and/or display antigens to serve as immunogenic antigen carriers for induction of protective immunity. Recent advances made in in vivo assembly of antigen-displaying polyester inclusions will be a focus. Particulate vaccines are inherently immunogenic due to enhanced ...
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    There is an unmet demand for safe and efficient vaccines for prevention of various infectious diseases. Subunit vaccines comprise selected pathogen specific antigens are a safe alternative to whole organism vaccines. However they often lack immunogenicity. Natural and synthetic self-assembling polymers and proteins will be reviewed in view their use to encapsulate and/or display antigens to serve as immunogenic antigen carriers for induction of protective immunity. Recent advances made in in vivo assembly of antigen-displaying polyester inclusions will be a focus. Particulate vaccines are inherently immunogenic due to enhanced uptake by antigen presenting cells which process antigens mediating adaptive immune responses. Bioengineering approaches enable the design of tailor-made particulate vaccines to fine tune immune responses towards protective immunity.
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    Journal Title
    Current Opinion in Biotechnology
    Volume
    48
    DOI
    https://doi.org/10.1016/j.copbio.2017.03.018
    Subject
    Biological sciences
    Engineering
    Medical biotechnology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/342782
    Collection
    • Journal articles

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