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dc.contributor.authorRehm, Bernd HA
dc.date.accessioned2017-07-28T03:56:58Z
dc.date.available2017-07-28T03:56:58Z
dc.date.issued2017
dc.identifier.issn0958-1669
dc.identifier.doi10.1016/j.copbio.2017.03.018
dc.identifier.urihttp://hdl.handle.net/10072/342782
dc.description.abstractThere is an unmet demand for safe and efficient vaccines for prevention of various infectious diseases. Subunit vaccines comprise selected pathogen specific antigens are a safe alternative to whole organism vaccines. However they often lack immunogenicity. Natural and synthetic self-assembling polymers and proteins will be reviewed in view their use to encapsulate and/or display antigens to serve as immunogenic antigen carriers for induction of protective immunity. Recent advances made in in vivo assembly of antigen-displaying polyester inclusions will be a focus. Particulate vaccines are inherently immunogenic due to enhanced uptake by antigen presenting cells which process antigens mediating adaptive immune responses. Bioengineering approaches enable the design of tailor-made particulate vaccines to fine tune immune responses towards protective immunity.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom42
dc.relation.ispartofpageto53
dc.relation.ispartofjournalCurrent Opinion in Biotechnology
dc.relation.ispartofvolume48
dc.subject.fieldofresearchMedical Biotechnology not elsewhere classified
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchTechnology
dc.subject.fieldofresearchcode100499
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode09
dc.subject.fieldofresearchcode10
dc.titleBioengineering towards self-assembly of particulate vaccines
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorRehm, Bernd


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