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dc.contributor.authorStruwe, Weston B.
dc.contributor.authorPagel, Kevin
dc.contributor.authorBenesch, Justin L.P.
dc.contributor.authorHarvey, David J.
dc.contributor.authorCampbell, Matthew P.
dc.date.accessioned2017-07-31T02:18:55Z
dc.date.available2017-07-31T02:18:55Z
dc.date.issued2016
dc.identifier.issn0282-0080en_US
dc.identifier.doi10.1007/s10719-015-9613-7en_US
dc.identifier.urihttp://hdl.handle.net/10072/342825
dc.description.abstractIon mobility mass spectrometry (IM-MS) is a promising analytical technique for glycomics that separates glycan ions based on their collision cross section (CCS) and provides glycan precursor and fragment masses. It has been shown that isomeric oligosaccharide species can be separated by IM and identified on basis of their CCS and fragmentation. These results indicate that adding CCSs information for glycans and glycan fragments to searchable databases and analysis pipelines will increase identification confidence and accuracy. We have developed a freely accessible database, GlycoMob (http://www.glycomob.org), containing over 900 CCSs values of glycans, oligosaccharide standards and their fragments that will be continually updated. We have measured the absolute CCSs of calibration standards, biologically derived and synthetic N-glycans ionized with various adducts in positive and negative mode or as protonated (positive ion) and deprotonated (negative ion) ions.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherSpringeren_US
dc.relation.ispartofpagefrom399en_US
dc.relation.ispartofpageto404en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalGlycoconjugate Journalen_US
dc.relation.ispartofvolume33en_US
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classifieden_US
dc.subject.fieldofresearchcode060199en_US
dc.titleGlycoMob: an ion mobility-mass spectrometry collision cross section database for glycomicsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text
gro.griffith.authorCampbell, Matthew


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