Show simple item record

dc.contributor.authorMoradali, M Fata
dc.contributor.authorGhods, Shirin
dc.contributor.authorRehm, Bernd HA
dc.date.accessioned2017-07-31T05:20:41Z
dc.date.available2017-07-31T05:20:41Z
dc.date.issued2017
dc.identifier.issn2235-2988
dc.identifier.doi10.3389/fcimb.2017.00039
dc.identifier.urihttp://hdl.handle.net/10072/342847
dc.description.abstractPseudomonas aeruginosa is an opportunistic pathogen affecting immunocompromised patients. It is known as the leading cause of morbidity and mortality in cystic fibrosis (CF) patients and as one of the leading causes of nosocomial infections. Due to a range of mechanisms for adaptation, survival and resistance to multiple classes of antibiotics, infections by P. aeruginosa strains can be life-threatening and it is emerging worldwide as public health threat. This review highlights the diversity of mechanisms by which P. aeruginosa promotes its survival and persistence in various environments and particularly at different stages of pathogenesis. We will review the importance and complexity of regulatory networks and genotypic-phenotypic variations known as adaptive radiation by which P. aeruginosa adjusts physiological processes for adaptation and survival in response to environmental cues and stresses. Accordingly, we will review the central regulatory role of quorum sensing and signaling systems by nucleotide-based second messengers resulting in different lifestyles of P. aeruginosa. Furthermore, various regulatory proteins will be discussed which form a plethora of controlling systems acting at transcriptional level for timely expression of genes enabling rapid responses to external stimuli and unfavorable conditions. Antibiotic resistance is a natural trait for P. aeruginosa and multiple mechanisms underlying different forms of antibiotic resistance will be discussed here. The importance of each mechanism in conferring resistance to various antipseudomonal antibiotics and their prevalence in clinical strains will be described. The underlying principles for acquiring resistance leading pan-drug resistant strains will be summarized. A future outlook emphasizes the need for collaborative international multidisciplinary efforts to translate current knowledge into strategies to prevent and treat P. aeruginosa infections while reducing the rate of antibiotic resistance and avoiding the spreading of resistant strains.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherFrontiers Research Foundation
dc.relation.ispartofpagefrom39-1
dc.relation.ispartofpageto39-29
dc.relation.ispartofissueFEB
dc.relation.ispartofjournalFrontiers in Cellular and Infection Microbiology
dc.relation.ispartofvolume7
dc.subject.fieldofresearchMicrobiology not elsewhere classified
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchcode060599
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0605
dc.titlePseudomonas aeruginosa lifestyle: A paradigm for adaptation, survival, and persistence
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
gro.rights.copyright© 2017 Moradali, Ghods and Rehm. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
gro.hasfulltextFull Text
gro.griffith.authorRehm, Bernd


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record