dc.contributor.author | Peraza, Luis R | |
dc.contributor.author | Nesbitt, David | |
dc.contributor.author | Lawson, Rachael A | |
dc.contributor.author | Duncan, Gordon W | |
dc.contributor.author | Yarnall, Alison J | |
dc.contributor.author | Khoo, Tien K | |
dc.contributor.author | Kaiser, Marcus | |
dc.contributor.author | Firbank, Michael J | |
dc.contributor.author | O'Brien, John T | |
dc.contributor.author | Barker, Roger A | |
dc.contributor.author | Brooks, David J | |
dc.contributor.author | Burn, David J | |
dc.contributor.author | Taylor, John-Paul | |
dc.date.accessioned | 2017-08-03T02:30:28Z | |
dc.date.available | 2017-08-03T02:30:28Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1065-9471 | |
dc.identifier.doi | 10.1002/hbm.23499 | |
dc.identifier.uri | http://hdl.handle.net/10072/343053 | |
dc.description.abstract | Mild cognitive impairment (MCI) is prevalent in 15%–40% of Parkinson's disease (PD) patients at diagnosis. In this investigation, we study brain intra- and inter-network alterations in resting state functional magnetic resonance imaging (rs-fMRI) in recently diagnosed PD patients and characterise them as either cognitive normal (PD-NC) or with MCI (PD-MCI). Patients were divided into two groups, PD-NC (N = 62) and PD-MCI (N = 37) and for comparison, healthy controls (HC, N = 30) were also included. Intra- and inter-network connectivity were investigated from participants’ rs-fMRIs in 26 resting state networks (RSNs). Intra-network differences were found between both patient groups and HCs for networks associated with motor control (motor cortex), spatial attention and visual perception. When comparing both PD-NC and PD-MCI, intra-network alterations were found in RSNs related to attention, executive function and motor control (cerebellum). The inter-network analysis revealed a hyper-synchronisation between the basal ganglia network and the motor cortex in PD-NC compared with HCs. When both patient groups were compared, intra-network alterations in RSNs related to attention, motor control, visual perception and executive function were found. We also detected disease-driven negative synchronisations and synchronisation shifts from positive to negative and vice versa in both patient groups compared with HCs. The hyper-synchronisation between basal ganglia and motor cortical RSNs in PD and its synchronisation shift from negative to positive compared with HCs, suggest a compensatory response to basal dysfunction and altered basal-cortical motor control in the resting state brain of PD patients. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Wiley Online | |
dc.relation.ispartofpagefrom | 1702 | |
dc.relation.ispartofpageto | 1715 | |
dc.relation.ispartofissue | 3 | |
dc.relation.ispartofjournal | Human Brain Mapping | |
dc.relation.ispartofvolume | 38 | |
dc.subject.fieldofresearch | Neurosciences | |
dc.subject.fieldofresearch | Neurology and neuromuscular diseases | |
dc.subject.fieldofresearch | Cognitive and computational psychology | |
dc.subject.fieldofresearchcode | 3209 | |
dc.subject.fieldofresearchcode | 320905 | |
dc.subject.fieldofresearchcode | 5204 | |
dc.title | Intra- and inter-network functional alterations in Parkinson's disease with mild cognitive impairment | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Khoo, Tien Kheng | |