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dc.contributor.authorAguilera, Felipe
dc.contributor.authorMcDougall, Carmel
dc.contributor.authorDegnan, Bernard M
dc.date.accessioned2017-08-03T23:10:23Z
dc.date.available2017-08-03T23:10:23Z
dc.date.issued2017
dc.identifier.issn0737-4038
dc.identifier.doi10.1093/molbev/msw294
dc.identifier.urihttp://hdl.handle.net/10072/343143
dc.description.abstractMolluscs fabricate shells of incredible diversity and complexity by localized secretions from the dorsal epithelium of the mantle. Although distantly related molluscs express remarkably different secreted gene products, it remains unclear if the evolution of shell structure and pattern is underpinned by the differential co-option of conserved genes or the integration of lineage-specific genes into the mantle regulatory program. To address this, we compare the mantle transcriptomes of 11 bivalves and gastropods of varying relatedness. We find that each species, including four Pinctada (pearl oyster) species that diverged within the last 20 Ma, expresses a unique mantle secretome. Lineage- or species-specific genes comprise a large proportion of each species’ mantle secretome. A majority of these secreted proteins have unique domain architectures that include repetitive, low complexity domains (RLCDs), which evolve rapidly, and have a proclivity to expand, contract and rearrange in the genome. There are also a large number of secretome genes expressed in the mantle that arose before the origin of gastropods and bivalves. Each species expresses a unique set of these more ancient genes consistent with their independent co-option into these mantle gene regulatory networks. From this analysis, we infer lineage-specific secretomes underlie shell diversity, and include both rapidly evolving RLCD-containing proteins, and the continual recruitment and loss of both ancient and recently evolved genes into the periphery of the regulatory network controlling gene expression in the mantle epithelium.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofpagefrom779
dc.relation.ispartofpageto792
dc.relation.ispartofissue4
dc.relation.ispartofjournalMolecular Biology and Evolution
dc.relation.ispartofvolume34
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchEvolutionary biology
dc.subject.fieldofresearchEvolutionary biology not elsewhere classified
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3104
dc.subject.fieldofresearchcode310499
dc.subject.fieldofresearchcode3105
dc.titleCo-option and de novo gene evolution underlie molluscan shell diversity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
gro.hasfulltextFull Text
gro.griffith.authorMcDougall, Carmel


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