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dc.contributor.authorSantos, CY
dc.contributor.authorSnyder, PJ
dc.contributor.authorWu, WC
dc.contributor.authorZhang, M
dc.contributor.authorEcheverria, A
dc.contributor.authorAlber, J
dc.date.accessioned2017-08-08T00:48:12Z
dc.date.available2017-08-08T00:48:12Z
dc.date.issued2017
dc.identifier.issn2352-8729
dc.identifier.doi10.1016/j.dadm.2017.01.005
dc.identifier.urihttp://hdl.handle.net/10072/343500
dc.description.abstractAs the population ages due to demographic trends and gains in life expectancy, the incidence and prevalence of dementia increases, and the need to understand the etiology and pathogenesis of dementia becomes ever more urgent. Alzheimer's disease (AD), the most common form of dementia, is a complex disease, the mechanisms of which are poorly understood. The more we learn about AD, the more questions are raised about our current conceptual models of disease. In the absence of a cure or the means by which to slow disease progress, it may be prudent to apply our current knowledge of the intersection between AD, cardiovascular disease, and cerebrovascular disease to foster efforts to delay or slow the onset of AD. This review discusses our current understanding of the epidemiology, genetics, and pathophysiology of AD, the intersection between AD and vascular causes of dementia, and proposes future directions for research and prevention.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom69
dc.relation.ispartofpageto87
dc.relation.ispartofjournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
dc.relation.ispartofvolume7
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematology not elsewhere classified
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode110299
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode1109
dc.titlePathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorZhang, Mia


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