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dc.contributor.authorQuinn, Alexander
dc.contributor.authorKoopman, Peter
dc.date.accessioned2017-08-08T06:30:19Z
dc.date.available2017-08-08T06:30:19Z
dc.date.issued2012
dc.identifier.issn1526-8004
dc.identifier.doi10.1055/s-0032-1324718
dc.identifier.urihttp://hdl.handle.net/10072/343527
dc.description.abstractThe process of sex determination in mammals normally unfolds in three distinct stages: (1) establishment of chromosomal sex at fertilization (XX or XY); (2) commitment to the appropriate pathway of gonadal differentiation with respect to chromosomal sex, through the action (or absence) of the Y chromosome gene SRY; and (3) correct development of secondary sexual characteristics, including internal and external genitalia, in accordance with gonadal sex. At any of these three steps, the process of sex determination can go awry, leading to disorders of sexual development. In this article, we review the typical mechanism and process of mammalian sex determination, with an emphasis on the well-characterized mouse and human models. We also consider aberrant mammalian sex determination, focusing on examples of sex reversal stemming from gene defects.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherThieme Medical Publishers Inc
dc.relation.ispartofpagefrom351
dc.relation.ispartofpageto363
dc.relation.ispartofissue5
dc.relation.ispartofjournalSeminars in Reproductive Medicine
dc.relation.ispartofvolume30
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine not elsewhere classified
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchcode111499
dc.subject.fieldofresearchcode1114
dc.titleThe molecular genetics of sex determination and sex reversal in mammals
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Alex E.


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