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dc.contributor.authorLi, Fangfei
dc.contributor.authorGorle, Anil K
dc.contributor.authorRanson, Marie
dc.contributor.authorVine, Kara L
dc.contributor.authorKinobe, Robert
dc.contributor.authorFeterl, Marshall
dc.contributor.authorWarner, Jeffrey M
dc.contributor.authorKeene, F Richard
dc.contributor.authorCollins, J Grant
dc.contributor.authorDay, Anthony I
dc.date.accessioned2022-05-17T02:03:31Z
dc.date.available2022-05-17T02:03:31Z
dc.date.issued2017
dc.identifier.issn1477-0520
dc.identifier.doi10.1039/c7ob00724h
dc.identifier.urihttp://hdl.handle.net/10072/343707
dc.description.abstractThe relatively non-toxic family of cucurbit[n]uril, Q[n], have shown considerable potential in vitro as drug delivery agents, with only a few examples of pharmacokinetic (PK) studies for drug⊂Q[n]. Drug-free Q[n] PK studies are the next step in determining the pharmacological applicability in their drug delivery potential. The results for the first PK and bio-distribution of drug-free 14C-Q[7] are described for administration via intravenous (i.v.) and intraperitoneal (i.p.) dosing. A study of oral administration of drug-free 14C-Q[8] has also been undertaken to determine the time course for the gastrointestinal tract (GIT), absorption and subsequent bio-distribution. Q[10], a potential drug carrier for larger drugs, was evaluated for its effect on the PK profile of a dinuclear ruthenium complex (Rubb12), a potential antimicrobial agent. The Rubb12⊂Q[10] complex and free Rubb12 were administered by i.v. to determine differences in Rubb12 plasma concentrations and organ accumulation. Interestingly, the PK profiles and bio-distribution observed for Q[7] showed similarities to those of Rubb12⊂Q[10]. Drug-free Q[7] has a relatively fast plasma clearance and a generally low organ accumulation except for the kidneys. Drug-free Q[8] showed a low absorption from the GIT into the blood stream but the small percentage absorbed reflected the organ accumulation of Q[7]. These results provide a better understanding of the probable PK profile and bio-distribution for a drug⊂Q[n] through the influence of the drug delivery vehicle and the positive clearance of drug-free Q[n] via the kidneys supports its potential value in future drug delivery applications.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRSC Publishing
dc.relation.ispartofpagefrom4172
dc.relation.ispartofpageto4179
dc.relation.ispartofissue19
dc.relation.ispartofjournalOrganic and Biomolecular Chemistry
dc.relation.ispartofvolume15
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchMedicinal and biomolecular chemistry not elsewhere classified
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode340499
dc.subject.fieldofresearchcode3405
dc.titleProbing the pharmacokinetics of cucurbit[7, 8 and 10]uril: And a dinuclear ruthenium antimicrobial complex encapsulated in cucurbit[10]uril
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by-nc/3.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2017. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) License, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorGorle, Anil Kumar


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