dc.contributor.author | Li, Fangfei | |
dc.contributor.author | Gorle, Anil K | |
dc.contributor.author | Ranson, Marie | |
dc.contributor.author | Vine, Kara L | |
dc.contributor.author | Kinobe, Robert | |
dc.contributor.author | Feterl, Marshall | |
dc.contributor.author | Warner, Jeffrey M | |
dc.contributor.author | Keene, F Richard | |
dc.contributor.author | Collins, J Grant | |
dc.contributor.author | Day, Anthony I | |
dc.date.accessioned | 2022-05-17T02:03:31Z | |
dc.date.available | 2022-05-17T02:03:31Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1477-0520 | |
dc.identifier.doi | 10.1039/c7ob00724h | |
dc.identifier.uri | http://hdl.handle.net/10072/343707 | |
dc.description.abstract | The relatively non-toxic family of cucurbit[n]uril, Q[n], have shown considerable potential in vitro as drug delivery agents, with only a few examples of pharmacokinetic (PK) studies for drug⊂Q[n]. Drug-free Q[n] PK studies are the next step in determining the pharmacological applicability in their drug delivery potential. The results for the first PK and bio-distribution of drug-free 14C-Q[7] are described for administration via intravenous (i.v.) and intraperitoneal (i.p.) dosing. A study of oral administration of drug-free 14C-Q[8] has also been undertaken to determine the time course for the gastrointestinal tract (GIT), absorption and subsequent bio-distribution. Q[10], a potential drug carrier for larger drugs, was evaluated for its effect on the PK profile of a dinuclear ruthenium complex (Rubb12), a potential antimicrobial agent. The Rubb12⊂Q[10] complex and free Rubb12 were administered by i.v. to determine differences in Rubb12 plasma concentrations and organ accumulation. Interestingly, the PK profiles and bio-distribution observed for Q[7] showed similarities to those of Rubb12⊂Q[10]. Drug-free Q[7] has a relatively fast plasma clearance and a generally low organ accumulation except for the kidneys. Drug-free Q[8] showed a low absorption from the GIT into the blood stream but the small percentage absorbed reflected the organ accumulation of Q[7]. These results provide a better understanding of the probable PK profile and bio-distribution for a drug⊂Q[n] through the influence of the drug delivery vehicle and the positive clearance of drug-free Q[n] via the kidneys supports its potential value in future drug delivery applications. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | RSC Publishing | |
dc.relation.ispartofpagefrom | 4172 | |
dc.relation.ispartofpageto | 4179 | |
dc.relation.ispartofissue | 19 | |
dc.relation.ispartofjournal | Organic and Biomolecular Chemistry | |
dc.relation.ispartofvolume | 15 | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry not elsewhere classified | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 340499 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.title | Probing the pharmacokinetics of cucurbit[7, 8 and 10]uril: And a dinuclear ruthenium antimicrobial complex encapsulated in cucurbit[10]uril | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | https://creativecommons.org/licenses/by-nc/3.0/ | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © The Author(s) 2017. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) License, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Gorle, Anil Kumar | |